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Studium bioaktivace vybraných proléčiv
Vernerová, Monika ; Kovaříková, Petra (advisor) ; Kastner, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Monika Vernerová Supervisor: Assoc. Prof. PharmDr. Petra Kovaříková, Ph.D. Consultant: Kristiina Huttunen, Ph.D., School of Pharmacy, Faculty of Health Sciences, Kuopio, University of Eastern Finland Title of thesis: Bioactivation study of selected pro-drugs This thesis deals with an enzymatic bioactivation study of the valproic acid's pro- drug. The evaluation was based on the data obtained from the HPLC analysis with appropriate method. The incubation reactions were carried out in a presence of different biological tissues, but also with isolated enzymatic fractions. The half-life of each bioactivation reaction was calculated from the gained results. It was also observed, if the bioconversion of the pro-drug to the parent drug, valproic acid, had been occured. These in vitro results will help to analyse samples from following in vivo experiments and help in designing better pro-drugs in future.
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