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Interactions of antiretrovirals with drug transporters; role in pharmacokinetics
Řezníček, Josef ; Štaud, František (advisor) ; Chládek, Jaroslav (referee) ; Trejtnar, František (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Josef Řezníček Supervisor: prof. PharmDr. František Štaud, Ph.D. Consultant: doc. PharmDr. Martina Čečková, Ph.D. Title of doctoral thesis: Interactions of antiretrovirals with drug transporters; role in pharmacokinetics Current pharmacotherapy of HIV positive patients consists of co-administration of three or more antiretrovirals from different pharmacotherapeutic groups, so called combination antiretroviral therapy (cART). Using this approach, a significant reduction in viral load, delayed viral resistance progression and prolonged efficacy of therapy is achieved. However, the use of cART often bears the risk of drug-drug interactions, which may result in subtherapeutic or supratherapeutic concentrations of drugs in organism with subsequent failure of therapy, or manifestation of toxic effects. Drug transporters expressed in many tissues of human body are widely responsible for occurrence of drug-drug interactions. Therefore, detailed knowledge on antiretrovirals pharmacokinetics and their interactions with drug transporters is important to ensure safe and effective therapy of HIV infection. The aim of this thesis was to study interactions of drugs used in combination antiretroviral...
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