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Epigenetic mechanisms in psychostimulant addiction
 Kubátová, Eliška ; Novotný, Jiří (advisor) ; Rydzyková, Tereza (referee)
Psychostimulants are highly addictive substances that act in a brain reward center by increasing extracellular levels of monoamines. In western civilization, they have gained popularity during the 20th century. Psychostimulant addiction is a persistent social problem even today since therapy is often unsuccessful and former users relapse frequently. Alterations in gene expression occur after psychostimulant is administered. These changes are long-lasting as they can often persist for weeks and months. This work focuses on the epigenetic changes in a brain associated with the development of addiction after psychostimulant administration. Key words: Epigenetics, psychostimulants, amphetamine, methamphetamine, cocaine, addiction
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