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The study of possible use of sertraline against gastrointestinal nematodes
 Vodvárková, Nikola ; Skálová, Lenka (advisor) ; Vokřál, Ivan (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Nikola Vodvárková Supervisor: prof. RNDr. Lenka Skálová, Ph.D. Title of diploma thesis: The study of possible use of sertraline against gastrointestinal nematodes Haemonchus contortus is a widespread parasitic nematode infecting the gastrointestinal tract of many small ruminants that causes enormous damage to animal production every year. It is responsible for a disease in its host called Haemonchosis the main characteristic of which is anaemia caused by severe blood loss. This is responsible for the reduced productivity of the animal, and in some cases results in the death of the host. A relatively limited range of anthelmintic drugs is used for the treatment of Haemonchosis with new substances rarely being added to the list of treatments. Due to the massive use of the same anthelmintic drugs and the parasites adaptability, extensive resistance is pervasive with current treatments being no longer effective. For this reason it has become necessary to look for new effective drugs that have a different mechanism of action (MOA). One possibility is to test the anthelmintic efficacy of common drugs from other therapeutic groups. In this work, the potential anthelmintic effect, metabolism and toxicity...
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