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Sarcopenia as a marker of severity of Parkinson's disease
 Vážná, Anna ; Růžička, Evžen (advisor) ; Dušek, Petr (referee)
The major focus of our study is use of the presence of sarcopenia as a marker for identification of Parkinson's disease in patients with RBD (REM sleep behaviour disorder). This intention is based on higher incidence of sarcopenia in patients with Parkinson's disease. We also evaluated connection of severity of Parkinson's disease and sarcopenia. In theoretical part of our thesis we present separately sarcopenia, Parkinson's disease and RBD for better understanding of these diseases and their connection. Our measurements of sarcopenia were based on literature review. We followed common approach of three component model of diagnosis of sarcopenia. Physical performance was evaluated based on gait characteristics. Low muscle strength was measured with handheld dynamometer. For estimation of body composition, we used two methods which were bioelectrical impedance analysis and anthropometry. In our research we measured these components in total on 72 males. This cohort was divided into three groups based on diagnosis. There were 32 patients with Parkinson's disease, 28 patients with RBD and 12 probands in control group. Based on our findings we defined suitable parameters and cut-off points for identification of sarcopenia as a marker of Parkinson's disease. In group of patients with Parkinson's disease...
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