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National Repository of Grey Literature

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Novel biologically active peptides from the venom of the solitary bee Macropis fulvipes (HYMENOPTERA: MELITTIDAE) Monincová, Lenka ; Slaninová, Jiřina ; Voburka, Zdeněk ; Hovorka, Oldřich ; Fučík, Vladimír ; Borovičková, Lenka ; Bednárová, Lucie ; Buděšínský, Miloš ; Straka, J. ; Čeřovský, Václav Two peptides (macropine-1 and macropin-2) were isolated, their structure determined by Edman degradation and mass spectrometry, which exhibited potent antimicrobial activity against both Gram-positive and -negative bacteria and moderate hemolytic activity against rat erythrocytes. We prepared several MAC-1 analogs to study the effect of their structure on antimicrobial and hemolytic activities. Detailed record

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