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Preparation of spray-dried lactose from high concentrated aqueous solutions
Souchová, Pavlína ; Svačinová, Petra (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Pavlína Souchová Title of Thesis: Preparation of spray-dried lactose from high concentrated aqueous solutions In this work, the effect of higher concentration of lactose aqueous solution dried at different temperatures on the properties of spray-dried powder was evaluated. Lactose solutions with concentrations of 30 %, 40 % and 50 % were prepared for evaluation. Each solution was spray dried at three inlet temperatures: 180 řC, 200 řC and 220 řC. The geometrical characteristics of the obtained particles were evaluated by optical microscopy and thermal properties using differential scanning calorimetry (DSC). Based on the results, it was found that, compared to the original material (D-lactose monohydrate), spray-dried samples contained spherical particles with the smooth surface, which slightly decreased in size. Most of the particles were in the range of 2.5 to 15 μm. On the contrary, particles smaller than 2.5 μm and larger than 20 μm occurred in very small quantities. During spray drying, slight changes in particle size were observed as a function of the inlet temperature. DSC thermograms showed glass transition temperature, crystallization and...
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