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Porphyrin-based porous frameworks
Hynek, Jan ; Lang, Kamil (advisor) ; Zimčík, Petr (referee) ; Dědic, Roman (referee)
Porous frameworks are a class of materials including metal-organic frameworks (MOFs), covalent organic frameworks (COFs) or conjugated microporous polymers (CMPs). Porous frameworks are widely studied as materials for gas storage and separation, catalysis, sensing, drug delivery, water purification, microelectronics, etc. The results presented in the Thesis document that porous frameworks with photoactive porphyrin molecules incorporated in the structure are photosensitizers of singlet oxygen, O2(1 g), and can be used for photodynamic applications including the construction of antibacterial coatings and of organized structures for photodynamic therapy. The Thesis presents a complex study of photophysical properties of porphyrin-based CMPs and COFs and, for the first time, demonstrates the application of porphyrin-based COFs for photodynamic inactivation of microorganisms. The CMPs and COFs were prepared by Suzuki-Miyaura cross-coupling and Schiff base formation, respectively. The materials were characterized by IR and solid-state NMR spectroscopy. The porosity of the materials was determined via N2 adsorption. The CMPs are microporous with pore sizes varying from 1.4 to 2.1 nm and with specific surface areas up to 624 m2 g-1 . On the other hand, the porphyrin-based COFs are only slightly...
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