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Evaluation of compressibility of acetylsalicylic acid
Pavelková, Petra ; Řehula, Milan (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Petra Pavelková Consultant: Doc. RNDr. Milan Řehula, CSc. Evaluation of compressibility of acetylsalicylic acid The aim of this thesis was evaluation of stability of acetylsalicylic acid from crystallographic aspect during compression process and to determine compressibility of this medical substance in the same time. For this purpose it was performed measurement of differential scanning calorimetry in range from - 30 žC to 220 žC by a speed of heating 10 žC/min. and cooling - 20 žC/min.. Further, the compaction equation, force-displacement record at compression forces ranging from 5 to 40 kN, and the stress relaxation at compression forces of 5, 10 and 15 kN were used. Measurement took place in specific conditions, which are described below. The experimental results showed following conclusions: The relation between the parameter E3 and compression force (LS) is non- linear and described by the equation: ESD3 = 0,086 LS + 0,013 LS2 - 0,211 R2 = 0,9999 The relation between plasticity and compression force (LS) is also non-linear and described by the equation: Pl = - 3,603 LS + 0,049 LS2 + 85,506 R2 = 0,9903 Values of the parameter PL show that ASA has a poor compressibility. At a...
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