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Microorganism based polyamines. Detection of prostate cancer
 Babková, Kateřina ; Opletalová, Veronika (advisor) ; Miletín, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Kateřina Babková Supervisor: Assoc. Prof. Veronika Opletalová, Ph. D. Specialized supervisor: Janne Weisell, Ph. D. Title of diploma thesis: Microorganism based polyamines. Detection of prostate cancer Prostate cancer is the most prevalent type of solid malignant tumour among men and the second highest cause of cancer related mortality of men after lung cancer. Every year the number of new cases is growing. To prevent this disease it is important to think about a healthy lifestyle and not to underestimate regular health checks because prevention and early diagnosis can bring better therapy results. Among others, prostate cancer can be diagnosed from urine samples. Increased levels of polyamines are the sign that something is wrong. Polyamines are ubiquitous in living mammalian cell, their metabolic pathways are still not clarified in depth but if a problem appears in their metabolism (for example enzyme overproducing, higher levels of any polyamine metabolite) it won't mean anything good. The aim of my work was to synthesize natural polyamines and their analogues which are produced by microorganism causing urinal infections of patients. Their metabolic end product can...
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