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Health Economy and Outcomes Research in the Health Technology Assessment in the Czech Republic
Klimeš, Jiří ; Vlček, Jiří (advisor) ; Foltán, Viliam (referee) ; Švihovec, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Jiří Klimeš, PharmD Supervisor Prof. RNDr. Jiří Vlček, CSc.; MUDr. Tomáš Doležal, PhD (consultant) Title of Doctoral Thesis Health Economy and Outcomes Research in the Health Technology Assessment in the Czech Republic The aim of PhD thesis was to present on practical examples of cost-of-illness (COI), cost- effectiveness (CEA), cost-utility (CUA) and outcomes research analyses their application within current HTA (Health Technology Assessment) process of drug technologies in the Czech Republic. HTA cover complex assessment of medicinal technologies/ interventions in terms of relative effectiveness, safety, health economic aspects (cost-effectiveness and budget impact) and ethical, social and legal aspects. It was presented a methodology of COI studies and their practical application (as the inputs) into CEA, CUA analyses within selected diseases - rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Moreover, it was presented concept of Markov cohort models used in CEA, CUA analyses in area of cardiovascular diseases, post-transplantation care, intensive care medicine and therapy of dementia. Within the CUA, it was interpreted a Probabilistic Sensitivity Analysis in...
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