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Synthesis of 1-(3-methoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine and study of its physicochemical properties
Valášková, Lenka ; Roh, Jaroslav (advisor) ; Vávrová, Kateřina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of inorganic and organic chemistry Candidate: Lenka Valášková Supervisor: PharmDr. Jaroslav Roh, PhD, Carine Deleuze-Masquefa Title of diploma thesis: Synthesis of 1-(3-methoxyphenyl)-N-methylimidazo[1,2- a]quinoxalin-4-amine and study of its physicochemical properties Melanoma is malign tumor usually located in the skin, mucous membranes or rarely in other parts of the organism. Every year the prevalence of this tumor is growing. Tumors which are detected in early stages can be successfully removed, but when metastasis appear treatment of this type of cancer is difficult. Some tumors (e.g. on problematic places such as on face) cannot be removed by surgery, even if they are soon detected. In these cases, topically administered anticancer drugs can be used. One of those substances is imiquimod (ALDARA® ; Figure 1), possesses antiviral, immunostimulating and cytotoxic activity. Limiting factor of this substance is its toxicity- it can be used only topically. The research group of prof. Pierre-Antoine Bonnet deals with the synthesis of imiquimod analogues. Synthesized molecules belong to three chemical groups, which differ in the orientation of imidazole moiety. Their lead structures, providing higher in vitro cytotoxic...
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