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Compressibility of the powder mixture with microcrystalline cellulose.
Hrdinová, Petra ; Řehula, Milan (advisor) ; Ďoubal, Stanislav (referee)
Compressing process can be evaluated by the parameters that are acquired from the record of force-run, stress relaxation or compaction equation. Compac- tion equation expresses the dependency on height, volume or density compression moulded material by pressure. In these thesis is pressing process characterized by parameters of compaction equation. Original Heckel equation declared range of pressing pressures, which caused plastic deformation of materials. Simultaneously pressed material is characterized by rate constant, expressing the rate of reduction of material in the plastic deformation. In these thesis is used triple - exponential equation, which was created at the Department of Pharmaceutical Technology and which is based on Cooper-Eaton equation. In a comparison between the Cooper- Eaton equation, the triple-exponential equation is not based on genuine values of density and detailed interpretation of the meaning of individual parameters. These thesis evaluates the granulate produced from a mixture of lactose monohydrate and microcrystalline cellulose and starch in mixtures where the microcrystalline cellulose is added at the concentration of 10, 20, 30, 40 %. The work results showed that with increasing reduction of volume, at the same time increases the volume of energy consumption and...
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