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Utilization of immiscible alloys for the SERS substrates
Klimšová, Zuzana ; Čupera, Jan (referee) ; Adam, Ondřej (advisor)
Surface-enhanced Raman spectroscopy (SERS) is an analytical method that enables the sensitive detection of biological molecules by enhancing the Raman signal on nanoporous metal substrates. This bachelor's thesis focuses on the preparation of immiscible alloys, specifically Cu75Ag25, using powder metallurgy and its application for SERS. The aim was to develop a fine-grained, two-phase microstructure suitable for SERS analysis. The process included mechanical alloying and isostatic pressing, followed by heat treatment to achieve the optimal microstructure. The results show that mechanical alloying and subsequent heat treatment create a fine two-phase microstructure suitable for further research as SERS substrates. The thesis also explores the possibility of preparing SERS substrates by casting and describes the structure of such prepared samples. The casting was conducted in a vacuum induction furnace, ensuring high material purity. Comparative studies between samples prepared by casting and powder metallurgy revealed differences in the resulting microstructures. The results indicate that powder metallurgy provides finer structures suitable for SERS applications, while cast samples exhibit coarser microstructures. Differential scanning calorimetry (DSC) was used to analyze the thermal properties of the samples, contributing to a better understanding of the kinetics of phase transformations. This thesis provides a comprehensive view of various methods for preparing SERS substrates and their impact on the resulting microstructures.
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