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Účinek suplementace anorganické formy selenu u králíků
VODIČKOVÁ, Lucie
Selenium is one of the most important microelements in the animal organism which acts through selenoproteins. However, both lack and excess have an negative impact on the organism. In this bachelor thesis we focused on the effect of supplementation of the inorganic form of selenium (sodium selenite). The experiment was performed on 18 rabbits of the chinchilla breed at the age of 7-10 months. The rabbits were divided into 3 groups (3 males, 3 females). The control group received the compound feed without added selenium. Group E1 received a feed ration with the addition of selenium at 0,15 mg per kg of dry matter and group E2 with the addition of 4,3 mg per kg of dry matter. In this experiment we deal with the influence of the inorganic form of selenium on the total weight of rabbits and selected organs (liver, kidneys, muscle), the influence of selenium supplementation on its content in these organs and also the influence on selenium content in rabbit blood serum and its effect on blood parameters. The results of our experiment showed histopathological changes only in group E2 in three individuals (50%). In two cases (33%), there were isolated small lymphocytic infiltrates in the interstitium and in one case (17%) the initial phase of glomerulonephrosis. No histological changes were found in the muscle tissue in either case.
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Vliv supranutričních dávek organické formy selenu na vybrané krevní parametry králíků
MIRANDOVÁ, Marie
Selenium is an important essential mikroelement, that acts through a number of selenoproteins. Both it´s lack, and it´s plenty has a negative influence on the organism. Recently is used Se during the various diseases treatment of people with supranutritive dosages of this element. The presented thesis deals with the supranutritive dosages influence of Selenium concentration organic form (Chlorella, enlarged alga with selenium) in blood serum and selected rabbits blood parameters (hemoglobin and hematocrit level, leukocytes and erythrocytes, urea concentration, triglycerides, gamma value glutamyltransfers and total concentration of plasmatical proteins). Nine week experiment was performed on 18 rabbits, which were divided in to three experimental groups. Group 1 (control group) has received the selenium at a dosage of 0.15 mg / kg dry matter of feed, group 2 at a dosage of 0.3 mg / kg dry matter feed and group 3 at a dosage of 4.3 mg / kg of dry matter feed. During the experiment weren´t registered any clinical symptoms associated with the possible Se toxicity. Supranutritive dosages in the group 3 led to faster and statistically significant increase of the selenium concentration in the blood serum. Parameters of the hemopoiesis, the growth and the substantial metabolism had no influnece with supranutritive dosages in the groups 2 and 3. The results has not confirmed the clear positive or negative effect of selenium supranutritive dosages on selected blood parameters. The results show, that after rabbits supplementation are suitable recommended dosages of 0.15 mg Se / kg dry matter feed.
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