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Manufacturing of calcium phosphates and silica based scaffolds for bioapllications
Virágová, Eliška ; Hadraba, Hynek (referee) ; Částková, Klára (advisor)
The aim of this diploma thesis was to prepare porous bioceramic scaffolds based on calcium phosphates and calcium phosphates doped with silica. Scaffolds are intended to be used in bone tissue engineering. Two main preparation methods were used for the creation of scaffolds – replica method and direct foaming method. Theoretical part of the diploma thesis is focused on a general description of the skeletal system, biomaterials and methods of preparation of highly porous calcium phosphate ceramics. Experimental part contains a description and the results of prepared scaffolds by above mentioned methods. The preparation process by the direct foaming method was optimized to obtain a defined structure. Calcium phosphate scaffolds containing 0–20 wt.% SiO2 were sintered and studied in terms of material characteristics (phase composition, pore size and porosity, microstructural study by scanning electron microscopy (SEM)), bioactive properties (simulated body fluid (SBF) interaction tests and tests of simulated degradation) and mechanical properties in order to evaluate the effect of silica doping. Scaffolds prepared by both methods were composed of a mixture of hydroxyapatite and/or tricalcium phosphate and cristobalite and wollastonite with comparable porosity in the range of 80–88 %. The pore size of the scaffolds prepared by the direct foaming method reached the interval of 5–250 µm opposite to template method reached the pore size up to 430 µm. The SBF interaction tests and tests of the simulated degradation confirmed the bioactive behavior of the prepared scaffolds and their ability to degrade under the simulated conditions. The scaffolds prepared by the direct foaming method showed better mechanical properties (compressive strength up to 1,8 MPa) than the scaffolds prepared by the template method. The results showed that the prepared scaffolds are suitable and promising for potential applications in bone tissue engineering.
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Processing and properties of porous bioceramic materials
David, Jakub ; Ručková, Jana (referee) ; Novotná, Lenka (advisor)
Bachelor thesis is focused on the study of bioceramic porous materials. The theoretical part is divided into three parts. The first part describes biomaterials, their division and use in bone tissue engineering. The second part deals with the requirements of bioceramic support systems (scaffolds). The third section describes methods for the porous structures production. The effort of the practical part was to prepare by method of direct foaming bioceramic porous materials based on calcium phosphate. It studied mainly the affect of the suspension composition on the final properties of the synthesized material. Morphology of materials was also evaluated using scanning electron microscopy. Degradability of materials in simulated body fluid was tested in terms of biological properties.
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Manufacturing of calcium phosphates and silica based scaffolds for bioapllications
Virágová, Eliška ; Hadraba, Hynek (referee) ; Částková, Klára (advisor)
The aim of this diploma thesis was to prepare porous bioceramic scaffolds based on calcium phosphates and calcium phosphates doped with silica. Scaffolds are intended to be used in bone tissue engineering. Two main preparation methods were used for the creation of scaffolds – replica method and direct foaming method. Theoretical part of the diploma thesis is focused on a general description of the skeletal system, biomaterials and methods of preparation of highly porous calcium phosphate ceramics. Experimental part contains a description and the results of prepared scaffolds by above mentioned methods. The preparation process by the direct foaming method was optimized to obtain a defined structure. Calcium phosphate scaffolds containing 0–20 wt.% SiO2 were sintered and studied in terms of material characteristics (phase composition, pore size and porosity, microstructural study by scanning electron microscopy (SEM)), bioactive properties (simulated body fluid (SBF) interaction tests and tests of simulated degradation) and mechanical properties in order to evaluate the effect of silica doping. Scaffolds prepared by both methods were composed of a mixture of hydroxyapatite and/or tricalcium phosphate and cristobalite and wollastonite with comparable porosity in the range of 80–88 %. The pore size of the scaffolds prepared by the direct foaming method reached the interval of 5–250 µm opposite to template method reached the pore size up to 430 µm. The SBF interaction tests and tests of the simulated degradation confirmed the bioactive behavior of the prepared scaffolds and their ability to degrade under the simulated conditions. The scaffolds prepared by the direct foaming method showed better mechanical properties (compressive strength up to 1,8 MPa) than the scaffolds prepared by the template method. The results showed that the prepared scaffolds are suitable and promising for potential applications in bone tissue engineering.
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Processing and properties of porous bioceramic materials
David, Jakub ; Ručková, Jana (referee) ; Novotná, Lenka (advisor)
Bachelor thesis is focused on the study of bioceramic porous materials. The theoretical part is divided into three parts. The first part describes biomaterials, their division and use in bone tissue engineering. The second part deals with the requirements of bioceramic support systems (scaffolds). The third section describes methods for the porous structures production. The effort of the practical part was to prepare by method of direct foaming bioceramic porous materials based on calcium phosphate. It studied mainly the affect of the suspension composition on the final properties of the synthesized material. Morphology of materials was also evaluated using scanning electron microscopy. Degradability of materials in simulated body fluid was tested in terms of biological properties.
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