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Role polymorfonukleárních leukocytů během zánětlivé odpovědi mléčné žlázy skotu
Steinerová, Michala
The mammary gland is an important production body in dairy cattle breeding. Due to breeding and hybridization programs it reached a position of highly functional exploitation body, which threatens its integrity and homeostasis. The most common health problem of dairy cows is mastitis. As a result, during the evolution, one of the most important defence mechanisms was created, an inflammatory response. It is divided into two stages: stage of initiation and resolution. In both of these stages, polymorphonuclear leukocytes (PMN) play very important role. They migrate from the bloodstream, adhere to the capillary walls, they get through them by diapedesis, and travel to the site of inflammation. There the elimination of pathogens through phagocytosis takes place. Then the damaged tissue is repaired. PMNs undergo apoptosis and they are phagocytosed by macrophages. Therefore, the aim of this work was to study recommended literature and to compile it into the literary research, which would summarize all findings about PMN's role during the inflammatory response of bovine mammary gland.
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Využití modelu virginní mléčné žlázy jalovice ke studium imunologických vlastností buněk obranného systému mléčné žlázy skotu
Vránová, Eliška
The mammary gland is the main production body in dairy cattle breeding. These days are current problems of mastitis disease of the mammary gland, which have an appreciable economic impact. Bachelor thesis briefly describes the anatomical structure of virgin mammary gland of non-pregnant heifers and discusses the use of model virgin mammary gland of heifers to study the immunological properties of the cell. Describes its first use, because the methodology used is the basis for subsequent work performed on virgin mammary gland. The work also aims to summarize the use of the model in research practice. Research reviewed the ultrastructure and functional characteristics of the cells before and during induced inflammation, its intensity and time of resolution by used agents. Furthermore, evaluating the pros and cons of using virgin mammary gland, compared to the adult mammary gland during involution, or lactation.
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