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A design of the system for continous evaluation of analytical samples quality in a clinical biochemistry laboratory
SVATOŠOVÁ, Kristýna
The aim of my work is to provide information about the process of evaluating analytic quality of samples. This kind of process is recommended in clinic biochemistry laboratory at present. Serum indexes are measured always, in any required sample test whose result can be influenced by sample quality. It is possible to evaluate the degree of haemolysis, icterus and lipemia in patients´ blood samples by the photometric method. The sample haemolysis is mostly caused by bad technic of blood samples taking or their inappropriate transport so that in the end of this process, in regular intervals there is a possibility to find out the level of results changes in connection with concrete laboratory services users. In theoretical part of my work I describe reasons of sample quality decreasing in vivo that´s something people can´t influence because they originate in a patient´s body and in vitro that are caused by wasteful manipulation. In this part there are also principles of the photometrical methods mostly used. The practical part contains the model example that shows how the analyts can be influenced by artificial adding of interfering substances. I could see increasing of some element concentration after making evaluation: Concentration of K increased by 24%, Fe by 10%, bilirubin by 13% and enzymatic activity ALT by 23%, AST by 179%, GMT by 26% and ALP was reduced by 25% in haemolytic serum. In icteric and lipemic serum there isn´t interference on such high level. Icterus causes decreasing of urea by 17%, creatinine by 27%, enzymatic activity ALT by 10% and activity GMT is increased by 11%. Lipemia decreases concentration of creatinine by 8%, enzymatic activity ALT by 6% and bilirubin is higher by 21%. In the end of my work I introduce statistic conclusion laboratory informatics system that gives laboratory management possibility to find out samples of bad quality in connection with concrete applicants and help to make some reparation.
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