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Thyroid disorders in pregnancy - immunoendocrinological and metabolic aspects
Vítková, Hana ; Jiskra, Jan (advisor) ; Kosák, Mikuláš (referee) ; Posová, Helena (referee)
Background: The immunological, hormonal and metabolic changes occur during pregnancy and increase the risk of developing some diseases. The aims of this study were: to compare serum concentrations of antibodies against C1q component of complement (anti-C1q) and mannose-binding lectin (MBL) in pregnant women with autoimmune thyroid disease (AITD) and healthy pregnant women and to compare urinary iodine concentration (UIC), neonatal thyroid stimulating hormone (TSH) and other thyroid laboratory parameters in pregnant women with gestational diabetes mellitus (GDM) and healthy pregnant women. Patients and methods: The "anti-C1q" study included 96 pregnant women with AITD and three control groups: 80 healthy pregnant women, 72 non-pregnant women with AITD and 72 healthy blood donors. The "MBL" study included 212 pregnant women with AITD and 80 healthy pregnant women, and the "urinary iodine concentration" study included 195 pregnant women with GDM and 88 healthy pregnant women. Anti-C1q and MBL concentrations were measured by ELISA, UIC by absorption spectrophotometry after previous alkaline demineralization, and other parameters by standard immunoassay. Results: The anti-C1q and MBL serum concentrations were higher in pregnant women with AITD compared to controls. The anti-C1q concentrations were...
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Iodine status among pregnant diabetic women
Radiměřská, Veronika ; Jiskra, Jan (advisor) ; Límanová, Zdeňka (referee)
Inroduction: The target of practical part was to verify the concentration of iodine in the urine (UIC) and its relation to the other thyroid parameters in the blood of pregnant diabetic women in second or third trimester of pregnancy. Methods: We have measured UIC in 163 pregnant women screened positive for pregestational or gestational diabetes in second trimester of pregnancy. I have worked later with results from 154 of them. Currently, serum levels of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb), thyroid-stimulating hormone (TSH), free thyroxine (FT4) and trijotyronin (FT3) were determined. Results: Median UIC was 91,15 ug/L (range 67,7-112 ug/l). At 136/154 (88 %) women UIC was lower than 150 ug/L, median 86,95 ug/L (range 64,95-106,4) and at 90/154 (58 %) was lower than 100 ug/L. UIC in the range with mild iodine deficiency (50-149 ug/L) was measured at 117/154 (76 %) women and 19 (12,3 %) values were found in the range of moderate UIC deficiency (20-49 ug/L). No value of UIC was lower than 20 ug/L. At 7 (4,5 %) women were measured levels in the adequate range for pregnant women (150-249 ug/L). At 11 women (7,2 %) was UIC higher than 250 ug/L. Conclusion: At 88 % pregnant diabetic women in second or third trimester of pregnancy was identified UIC values at...
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Iodine status among pregnant diabetic women
Radiměřská, Veronika ; Jiskra, Jan (advisor) ; Límanová, Zdeňka (referee)
Inroduction: The target of practical part was to verify the concentration of iodine in the urine (UIC) and its relation to the other thyroid parameters in the blood of pregnant diabetic women in second or third trimester of pregnancy. Methods: We have measured UIC in 163 pregnant women screened positive for pregestational or gestational diabetes in second trimester of pregnancy. I have worked later with results from 154 of them. Currently, serum levels of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb), thyroid-stimulating hormone (TSH), free thyroxine (FT4) and trijotyronin (FT3) were determined. Results: Median UIC was 91,15 ug/L (range 67,7-112 ug/l). At 136/154 (88 %) women UIC was lower than 150 ug/L, median 86,95 ug/L (range 64,95-106,4) and at 90/154 (58 %) was lower than 100 ug/L. UIC in the range with mild iodine deficiency (50-149 ug/L) was measured at 117/154 (76 %) women and 19 (12,3 %) values were found in the range of moderate UIC deficiency (20-49 ug/L). No value of UIC was lower than 20 ug/L. At 7 (4,5 %) women were measured levels in the adequate range for pregnant women (150-249 ug/L). At 11 women (7,2 %) was UIC higher than 250 ug/L. Conclusion: At 88 % pregnant diabetic women in second or third trimester of pregnancy was identified UIC values at...
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