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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
The Shared Steps of Lincomycine and Pyrrolo-benzodiazepine Biosynthetic Pathways.
 Jiráčková, Petra ; Janata, Jiří (advisor) ; Fišer, Radovan (referee)
Lincomycin and its semi-synthetic derivate clindamycin are therapeutically used antibiotics inhibiting protein synthesis in sensitive bacteria. Their structure is composed of an amino-sugar and an amino-acid moiety, which are linked with an amide bond. Some time ago the sequence of lincomycin-production gene cluster was established and functions of the most proteins coded from gene cluster were proposed on the basis of a comparison with known proteins and gene-inactivations. For a long time it was clear that the amino-acid moiety of linkomycin (propylproline) is related to a dihydropyrrol moiety of pyrrolo[1,4]benzodiazepine (PBD). Both of these moieties are derived from L-tyrosine and they undergo the same biosynthetic pathway at first. But other biosynthetic steps divide. It is believed that a transfer of genes from the PBD-production gene cluster to the lincomycin-production gene cluster could modify the structure of propylproline and improve traits of lincomycin e.g. increase antimalaric effects. The most effective antibiotics are alkyl derivatives, their chemical synthesis is very complicated, but they could be prepared via genetic engineering as so-called hybrid antibiotics.
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The Shared Steps of Lincomycine and Pyrrolo-benzodiazepine Biosynthetic Pathways.
 Jiráčková, Petra ; Fišer, Radovan (referee) ; Janata, Jiří (advisor)
Lincomycin and its semi-synthetic derivate clindamycin are therapeutically used antibiotics inhibiting protein synthesis in sensitive bacteria. Their structure is composed of an amino-sugar and an amino-acid moiety, which are linked with an amide bond. Some time ago the sequence of lincomycin-production gene cluster was established and functions of the most proteins coded from gene cluster were proposed on the basis of a comparison with known proteins and gene-inactivations. For a long time it was clear that the amino-acid moiety of linkomycin (propylproline) is related to a dihydropyrrol moiety of pyrrolo[1,4]benzodiazepine (PBD). Both of these moieties are derived from L-tyrosine and they undergo the same biosynthetic pathway at first. But other biosynthetic steps divide. It is believed that a transfer of genes from the PBD-production gene cluster to the lincomycin-production gene cluster could modify the structure of propylproline and improve traits of lincomycin e.g. increase antimalaric effects. The most effective antibiotics are alkyl derivatives, their chemical synthesis is very complicated, but they could be prepared via genetic engineering as so-called hybrid antibiotics.
Detailed record
The use of cereals for energy purposes
 KŇOURKOVÁ, Alena
The aim of this work is to provide a summary of the utilization of cereals in the field of energy production split by the individual grain groups. The grains are divided into two main groups whereas both can be utilized as a source of biomass. Among the most popular oil plants utilized for energy purposes belong oilseed rape and maize. Both are grown as hybrids which are utilized for energy purposes exclusively. Within the category of hybrids a slow starch deposition can be achieved as well as efficient growth of cellulose, the plant materiál which is important for the combustion. The management of biomass production must také into account the capability of our agriculture and the principles of sustainable utilization of soil and landscape.
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