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	Cancer immunotherapy based on the combination of TLR ligands and ligands of phagocytic receptors UHER, Ondřej The main goal of this thesis was to study cancer immunotherapy based on combination of TLR ligands and ligands of phagocytic receptors. We studied replacement of LPS by bacterium Borrelia burgdorferi or Resiquimod in cancer immunotherapy. We also tried to block CD47 in cancer immunotherapy. The last aim of this thesis was phosphatidylserine expression on melanoma cells B16-F10. Detailed record
	Studium mechanismů nádorové imunoterapie založené na kombinaci resiquimodu s kotveným mananem a její další optimalizace PAĎOUKOVÁ, Lucie The aim of this thesis was to analyse the tumour infiltration, identify the content of the infiltrate and determine inflammatory cytokine IFN-gamma. We also studied the possibilities of strengthening immunotherapeutic effect. Detailed record
	Nádorová imunoterapie založená na mechanizmech vrozené imunity a její optimalizace MASÁKOVÁ, Kamila The aim of this thesis was to study the effect of intratumoral aplication of various combinations of TLR agonist and compounds stimulating phagocytosis on reduction of tumor size. The effect of immunotherapy was studied using different models of tumors. The cytotoxic effect of activated neutrophils on melanoma cell was studied as well. Detailed record
	Nádorová imunoterapie založená na kombinaci TLR7 signalizace a aktivace fagocytózy nádorových buněk. Studium mechanismů a zesílení účinku KVARDOVÁ, Karolína The aim of this thesis was to study cancer immunotherapy based on combination of TLR7 signalling and activation of phagocytosis of cancer cells. We studied the influence of our immunotheraphy on parallel untreated tumor. Mechanisms of therapy were studied in vitro. The possibility to enhance therapeutic effect using more complex mixture of TLR agonists was studied as well. Detailed record
	Studium mechanismů působících při nádorové imunoterapii založené na instalaci ligandů fagocytárních receptorů na povrch nádorových buněk SVÁČKOVÁ, Denisa The aim of thesis was to study murine melanoma B16- F10 therapy based on the use of TLR agonists combinedwith activation of phagocytosis. Mechanisms of this therapy were studied on the bases of analysis of tumor infiltrating immune cells and evaluationof thein effect on tumor cells. Detailed record
	Electron microscopic analysis of processes in progress during cancer immunotherapy based on use of TLR agonists and the ligands of phagocytic receptors NEDBALOVÁ, Pavla The ligands of phagocytic receptors anchored in the membrane of tumour cells in combination with TLR agonists cause strong neutrophils infiltration within the tumour. These neutrophils are able to direct tumour cell lysis. Ultrastructure analysis of tumour with aim to determine mechanisms of tumour cell damage by neutrophils was performed with transmission electron microscope. Detailed record
	Searching for Toll-like receptors agonists that would interact synergistically with ligands of phagocytic receptors and that could be used in cancer immunotherapy in human medicine LENZOVÁ, Zuzana The goal of this thesis was to find agonists of Toll-like recptors that would interact with ligands of phagocytic receptors synergistically, would cause a strong suppresion of tumour growth, and could be safely used in human medicine. Detailed record
	Study of clinically applicable cancer immunotherapy and their mechanisms GLASEROVÁ, Simona The aim of this thesis was study of replacement of LPS in innate immunity based cancer immunotherapy. Application of poly (I:C) with mixture of mannan-SMCC + R-848.HCl leads to synergy, higher reduction of tumor growth and significant prolongation of survival. The significance and mechanism of action of neutrophils have also been studied within this therapy. Detailed record
	Study of cancer therapy using cationic antimicrobial peptides HUSNÍKOVÁ, Hana The aim of these thesis was to study cationic antimicrobial peptides as new cytotoxic drugs for cancer treatment. We tried to compare the effect of various peptides on murine B16-F10 melanoma cells in both in vitro and in vivo experiments. Detailed record
	The application of the pathogen organisms and their parts to tumor immunotherapy CAISOVÁ, Veronika The present study is dealing with the possibility of the application either complete pathogen organisms or their parts to tumor immunotherapy. In addition, the complete process from the origin of the spontaneous regression induced by infection diseases leading to the current treatments using pathogen associated molecular patterns has been evaluated. Detailed record

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