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The Role of Dco in \kur{Drosophila} Haematopoiesis
JONÁTOVÁ, Lucie
Point mutations found in human breast cancer samples introduced into the Drosophila dco gene affect the Drosophila haematopoiesis. I described different haematopoietic phenotypes in such mutants and tested their connection with the Toll and the JAK/STAT signalling pathways.
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Occurrence of woman cervical cancer in South Bohemian Region.
NĚMCOVÁ, Eva
Cervical cancer represents an enormous health, psychological and social stress for every woman. The most important risk factor in the development of cervical carcinoma, which the second most common malignant cancer in women, is infection with a high-risk strain of human papillomavirus - a very frequent sexually transmitted disease. More than 100 types of HPV are acknowledged to exist, with HPV 16 and 18 being classified as high-risk types in particular. Worldwide, 500,000 new cases of cervical cancer are diagnosed every year. In the Czech Republic, there are 1,000 new cases of cervical cancer each year, out of which up to 400 women die. It is estimated that there will be up to 1,000,000 new cases of cervical cancer by 2050 unless the prevention is improved. Every woman is at risk of developing cervical cancer. HPV is sexually transmitted, however not only by sexual intercourse but also by skin-to-skin-contact with infected areas. Other risk factors in the development of the disease are: first sexual intercourse at early age, the number of sexual partners, smoking, other sexually transmitted diseases and a long term use of hormonal contraception. Use of condoms, which protects against sexually transmitted diseases, reduces the transmission of HPV by up to 70%. Having regular gynaecological check-ups with Pap smears is crucial for cervical cancer screening, as the screening suggests the presence of cytological abnormalities and pre-cancer. However, it cannot detect all types of premalignant changes and early stages of the carcinoma. Two vaccines have recently been developed, effective against the most frequent oncogenic strains of HPV (16 and 18), which currently cause about 70% of cervical cancer cases. Active immunisation against human papillomavirus is the first vaccination against carcinoma. Together with screening, it represents the best prevention method against cervical carcinoma. Based on the research of technical literature, the first part of the dissertation gives an overall view of the issue of cervical carcinoma. The second part of the dissertation deals with the research, eliciting the knowledge and attitude of women from Southern Bohemian towns in the field of cervical carcinoma prevention in the period of December 2008 - March 2009 and comparing it to technical literature.
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Optimizing of (pro)enzyme therapy of cancer.
KALFERSTOVÁ, Lucie
The aim of this thesis was to optimize the proenzyme and enzyme therapy of the healthy and mice suffering of cancer and to clarify the mechanism of this therapy. We found optimal mode of application of therapeutic preparations. We studied changes of serum {$\alpha$}2-macroglobulin, total level of serum protease inhibitors, and free or latent TGF-{$\beta$} in various modes of experimental tumor therapies.
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The incidence, prevalence, letality and fatality from cancers in the Czech Republic
Křížová, Jana ; Mazouch, Petr (advisor) ; Malečková, Romana (referee)
In the past few decades, the Czech Republic took place significant changes in mortality rates. The objective of this study is to determine the development of cancer in the Czech Republic over the last forty years. Indicators of morbidity and mortality are being used. Emphasis is placed on the current development of all cancers in this country and further detail on those cancers that affect most of our population. In the very end, based on the results of the mortality tables, are analyzed the changes in life expectancy depending on the elimination of the deaths of some cancers. This model can use as an idea of how many years would, on average, our population lingered longer, if the cancer did not cause of death.
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HOW EDUCATION AFFECTS WOMEN IN THE VYSOČINA REGION TO USE A POSSIBILITY OF CERVICAL CANCER VACCINATION
ŠIDLÁKOVÁ, Lenka
The bachelor´s work captures a level of knowledge of present-day girls and young women about cervical cancer. It shows their attitude towards the possibility of cervical cancer vaccination, if they know the fees, a number of doses, risk factors etc. The work is divided into two parts, a theoretical and a practical ones. The theoretical part describes the current status-the anatomy of female reproductive organs, the history, occurence, causes, transmission, symptoms, diagnoses, possibilities of treatment and mainly prevention. The practical part contains targets and hypotheses, methods, results of the research that are transferred into the graphs. The practical part also includes a discussion where the results, obtained through my own research, are thought about. The results are further compared with similar conclusions of other authors. All is completed by my own opinion.
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