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Ecotoxicological evaluation of the non-steroidal and anti-inflammatory drug
Horáková, Veronika ; Vytlačilová, Jitka (advisor) ; Karlíčková, Jana (referee)
Horáková Veronika, Ecotoxicological evaluation of the non-steroidal and anti- inflammatory drug, (graduation thesis) Charles University in Prague, Pharmaceutical Faculty in Hradec Králové, Department of Pharmaceutical Botany and Ecology; total number of pages: 67 There is getting more higher occurrence of residuals of healing substance connected with growing consumption of medicals in our environment, where they influence a range of organisms. In this work the ecotoxicity of diclofenac was monitored. Four tests of toxicity were selected for evaluation of this influence - one acute test (with Thamnocephalus platyurus), two semi-chronic tests (with Tetrahymena thermophila, Sinapis alba seeds) and one chronic test (with Brachionus calyciflorus). Values for diclofenac have been found from these tests: 24hEC50 5,058 mg/l - THAMNOTOXKIT FTM , 24h EC50 32,88 mg/l (23,07 - 46,86 mg/l) at 492 nm - more generation test with organism Tetrahymena thermophila, 48h EC50 1,363 mg/l (0,7848 - 2,366 mg/l) - ROTOXKIT F CHRONIC, 72h EC50 71,42 mg/l (62,51 - 81,60 mg/l) - a semi chronic test with Sinapis alba seeds. Key words: ecotoxicology, diclofenac, Tetrahymena thermophila, Thamnocephalus platyurus, Brachionus calyciflorus, Sinapis alba
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