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Pain perception in elders
Vítková, Jana ; Vaculín, Šimon (advisor) ; Telenský, Petr (referee)
The aging of the population is one of the problems of the current period. With increasing age, we have to deal with the accompanying phenomenon more and more - the pain which significantly inconveniences the life and makes normal integration of elderly people into society impossible. This bachelor thesis summarises the present knowledge of pain in elderly people. It addresses the mechanism of pain perception, physiology of aging and types of pain which occur in elderly people. Some types of pain are accompanying diseases which occur during old age - neuropathic, chronic and oncologic pains. The higher occurrence of these types of pain could be explained by the progressive degeneration of nerve system during aging, either due to demyelization and reduction of the number of nerve fibres or due to accumulation of free radicals in the organism. On the other hand, there are some types of pain which elderly people feel with lower intensity - visceral and postoperative pain. At the same time, the pain threshold is increasing in the elderly people. This paradox, i.e. on one hand higher occurrence of chronic pain at higher intensity and on the other hand reduction of visceral pain and postoperative pain could be explained by diffuse noxious inhibitory controls. The current knowledge of the pain in the elderly is...
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Pathological pain states, the role of synaptic modulation at spinal cord level
Nerandžič, Vladimír ; Paleček, Jiří (advisor) ; Krůšek, Jan (referee)
(English) Modulation of synaptic transmission in dorsal horn of spinal cord plays a key role in nociceptive signalling. Recent studies have indicated a great importance of presynaptic TRPV1 receptors (transient receptor potential vanilloid) in spinal cord. These receptors act as molecular integrator of nociceptive stimulation on periphery. The way of their activation and the effect on modulation of the synaptic transmission are not clarified yet. Previous studies demonstrated the influence of many inflammatory mediators and cytokins on TRPV1 receptors. The aim of our research was to show changes in activation of presynaptic TRPV1 receptors in the spinal cord following the application of endogenous agonist N-oleoyl dopamine (OLDA) in a model of peripheral neuropathy, after incubation with cytokine TNFα and to show the effect of precursor of anandamide N-acylphosphatidylethanolamine (NAPE). In our experiments, we have recorded miniature excitatory postsynaptic currents (mEPSC) from neurons of acute spinal cord slices by the patch-clamp method. The first series of experiments tested sensitivity to application of the endogenous agonist OLDA 5 days after evoking peripheral neuropathy. The frequency of mEPSC increased significantly - to 250 % of base level after applying a low concentration of OLDA (0,2...
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Possibilities and importance of physiotherapy in diabetic polyneuropathy
ŠTÍCHOVÁ, Kateřina
This bachelor thesis focuses on issues in diabetic polyneuropathy. Diabetic polyneuropathy is one of the most frequent chronical complications in internal disease diabetes mellitus. The point is that the functions of peripheral nerves are being destroyed sensitive, motoric, even the autonomous ones. The destruction of these nerves is based on longstanding hyperglycaemia. Due to the variability of levels and localizations of afflictions, polyneuropathy is characterized by a huge amount of clinical symptoms pain, paraesthesia, amyosthenia, paresis etc. This disease is always very uncomfortable for a patient and it can be the cause of invalidity in the future. The main objective of the thesis is to bring fundamental theoretic information about diabetes mellitus and diabetic polyneuropathy and notify about possibilities of physiotherapy in therapy and prevention. To reach the research objective, I get some of physiotherapeutic methods to practice and then I evaluate the effectivity of therapy. First two chapters of the theoretical part describe diabetes mellitus and diabetic polyneuropathy in general. They contain a brief anatomy and basic information of these diseases. Chapter three comprises investigations that were used in diagnostics of the diabetic polyneuropathy. Fourth part informs about overall therapy and at the end the fifth is about possibilities of physiotherapy within a frame of polyneuropathy. In the experimental section of thesis, a qualitative form of research was chosen. It was performed by six patients, came from the Internal Practice of MUDr. Jitka Brádlerová, Aurora Spa, Třeboň. By the five of them, the diabetic polyneuropathy was actually diagnosed and by the last one it is in a phase of suspicion. Each of the patients' case report brings detailed anamnesis, kinesiology analyse, basic neurological examinations and two versions of the rehabilitation plan short and long-term one. There is subjective and objective evaluation of therapy's effectivity in the chapter seven, that is also annotated in discussion and conclusion of thesis. All the patients acknowledged an improvement in their status and that proclaims the therapy was selected properly. Bachelor theses can be useful as a comprehensive summary of information about diabetes mellitus and diabetic polyneuropathy, physiotherapeutic methods and their importance in the therapy of these diseases for physiotherapy students, physiotherapists, other medical staff even the laic public.
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