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National Repository of Grey Literature

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In vitro assessment of antiproliferative effects of novel intracellular iron chelators Macková, Eliška ; Kvasničková, Eva (referee) ; Šimůnek, Tomáš (advisor) Charles rnáversáty án mrague caculty of mharmacy án eradec hrálové aeéartment of Báochemácal pcáences CandádateW bláška jacková puéervásorW aocK mharmarK Tomáš ŠámůnekI mhKaK Tátle of dáéloma thesásW In vitro assessment of antáéroláferatáve effects of novel ántracellular áron chelators Aroylhydrazones are trádentate láéofálác áron chelators wáth very good entry to cellsK fn our éreváous exéerámentsI salácylaldehyde ásonácotánoyl hydrazone EpfeFI has shown very ánterestáng antáoxádant and antáéroláferatáve effácáencáes K eoweverI áts major dásadvantage ás low stabáláty caused by a fast hydrolysás of hydrazone bondK ThereforeI the seráes of náne new analogues of pfe deráved from aromatác ketones has been synthetázed at the aeéartment of fnorganác and lrganác Chemástry of our facultyK lur recent study extends our éreváous exéeráments wáth these substances and examánes éotentáal use of these new aroylhydrazones án antátumour treatmentK The breast adenocarcánoma cell láne jCc-T and human éromyelocytác leukemáa cell láne eiSM were usedK mroláferatáon tests took TO hoursI when cells were exéosed to actáon of substances or theár combánatáons ptatástácally ságnáfácant antáéroláferatáve actáváty was noted án all new chelators at the both cell lánesK te coméared the fC5M values of each chelator to cancer cell... Detailed record

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