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The role of branched-chain amino acids in nutrition of strength athletes
Jelínková, Kristýna ; Caha, Jan (advisor) ; Vebr, Pavel (referee)
These are a significant group of essential amino acids - branched chain amino acids, including leucine, isoleucine and valine. There is evidence to suggest that supplementation of branched amino acids can be very beneficial for synthesis and reduction of muscle protein degradation in strength athletes. On the other hand, there are studies to find that BCAA supplementation is not useful for restoring damaged muscles and alleviating pain after exercise as expected. The aim of this work is to summarize the issue of branched amino acid metabolism and to compare their effects when used in the form of BCAA supplements in strength athletes. Keywords: amino acids, leucin, BCAA, fitness, strength, muscles
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The role of C-reactive protein in cardiac ischemic tolerance
Perglerová, Aneta ; Neckář, Jan (advisor) ; Vebr, Pavel (referee)
Ischemic heart disease (CHD) is a set of pathophysiological states, disorders of blood flow and oxygen supply of the myocardium due to vascular constriction or thrombus blockage. Inflammation plays an important role in CHD. The inflammatory response is associated with the synthesis of acute phase proteins in the liver such as C-reactive protein (CRP). CRP plays an important role in acute forms of CHD such as myocardial infarction (MI). The development of CHD may be supported by the occurrence of some of the risk factors (eg. atherosclerosis, hypertension, plasma CRP). Increased CRP levels may support the initiation of atherosclerotic plaque formation as well as in the case of hypertension the presence of CRP increases the risk of developing CHD. The healing proces after acute MI is accompanied by an inflammatory phase where CRP occurs naturally and CRP is important to accelerate inflammation. There may be a situation which inflammation goes into a chronic phase because it is not terminated in time, with constant CRP synthesis. High levels of CRP may decrease the prognosis after MI. The elevated plasma CRP has a negative effect on the expansion of MI and the associated ventricular dilatation, which may result in a rupture of the cardiac wall. Hypertrophy is the compensatory mechanism of the...
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Ischemia-reperfusion injury in cold acclimated rats
Vebr, Pavel ; Žurmanová, Jitka (advisor) ; Alánová, Petra (referee)
The effect of cold acclimation on body of mammals has been studied for many decades by using relatively low temperatures for acclimation (6-10 řC). The results of these experiments have shown the important role of the adrenergic and thyroid system during acclimation and negative impact on renal system at the same time. In contrast, a recent study on winter swimmers suggests a possibility of positive influence of hardening on cardiovascular system. There is no available study investigating a relationship between cold adaptation and ischemia-reperfusion injury. The aim of this study was to establish a protocol of isolated rat heart and its fixation at our workplace. Furthermore, to find the impact of mild cold acclimation on the ischemia-reperfusion injury of rat. Methods of ex vivo heart perfusion and fixation were successfully established. The effect of 5 weeks long cold acclimation in 10 ± 2 řC on left ventricle ischemia-reperfusion injury was observed. Powered by TCPDF (www.tcpdf.org)
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The role of C-reactive protein in cardiac ischemic tolerance
Perglerová, Aneta ; Neckář, Jan (advisor) ; Vebr, Pavel (referee)
Ischemic heart disease (CHD) is a set of pathophysiological states, disorders of blood flow and oxygen supply of the myocardium due to vascular constriction or thrombus blockage. Inflammation plays an important role in CHD. The inflammatory response is associated with the synthesis of acute phase proteins in the liver such as C-reactive protein (CRP). CRP plays an important role in acute forms of CHD such as myocardial infarction (MI). The development of CHD may be supported by the occurrence of some of the risk factors (eg. atherosclerosis, hypertension, plasma CRP). Increased CRP levels may support the initiation of atherosclerotic plaque formation as well as in the case of hypertension the presence of CRP increases the risk of developing CHD. The healing proces after acute MI is accompanied by an inflammatory phase where CRP occurs naturally and CRP is important to accelerate inflammation. There may be a situation which inflammation goes into a chronic phase because it is not terminated in time, with constant CRP synthesis. High levels of CRP may decrease the prognosis after MI. The elevated plasma CRP has a negative effect on the expansion of MI and the associated ventricular dilatation, which may result in a rupture of the cardiac wall. Hypertrophy is the compensatory mechanism of the...
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The role of hypoxia inducible factor-1α in the progression of chronic heart failure
Kordač, Petr ; Neckář, Jan (advisor) ; Vebr, Pavel (referee)
Transcription factor hypoxia inducible factor-1α (HIF-1α) is a key regulator of physiological and cellular mechanisms to adapt to deficiency of oxygen. In hypoxia (or ischemia) HIF-1α level increases as HIF-1α-degrading enzymes prolyl hydroxylases are inactive due to low oxygen level. HIF-1α plays also essential role in triggering cellular protection and metabolic alteration during pathophysiological conditions in the heart. It has been suggested that stabilization of HIF-1α in myocardium may prevent deleterious remodelling induced by various forms of chronic heart failure (CHF). The project aims to outline current knowledge about the role of HIF-1α in the progression of CHF.
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The role of branched-chain amino acids in nutrition of strength athletes
Jelínková, Kristýna ; Caha, Jan (advisor) ; Vebr, Pavel (referee)
These are a significant group of essential amino acids - branched chain amino acids, including leucine, isoleucine and valine. There is evidence to suggest that supplementation of branched amino acids can be very beneficial for synthesis and reduction of muscle protein degradation in strength athletes. On the other hand, there are studies to find that BCAA supplementation is not useful for restoring damaged muscles and alleviating pain after exercise as expected. The aim of this work is to summarize the issue of branched amino acid metabolism and to compare their effects when used in the form of BCAA supplements in strength athletes. Keywords: amino acids, leucin, BCAA, fitness, strength, muscles
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Analysis of the lifestyle of members of the Criminal Investigation Service and the Regional Police Directorate of the South Bohemian Region.
VEBR, Pavel
The theoretical part is focused on the Police of the Czech Republic. Activities and characteristics of the Criminal Police and Investigation Sevice are described; the Police of the Czech Republic is also depicted as a social group. I also describe the lifestyle of police officers and the factors influencing it, such as nutrition, sleep or stress. The practical part was done in a form of questionaire at selected departments of the Criminal Police and Investigation Service. The questions were aimed at the lifestyle of the responding crminialists and result are described in this part of the thesis.
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Remote ischemic conditioning: principles and mechanisms
Chmelířová, Kateřina ; Novotný, Jiří (advisor) ; Vebr, Pavel (referee)
Ischemic remote conditioning is an experimental treatment method serving for the protection of heart (or other organs) against ischemia-reperfusion injury. In comparison with the regular conditioning, where the process is initiated by sequence of short ischemias performed directly on the target organ, protective function of the remote conditioning is activated via sequence of short ischemias and following reperfusions executed on a remote tissue - usually by strangulating an upper limb. Transmission of the signal from the remote organ to the target organ is mediated via neuronal and humoral routes. Method can be applied as pre-conditioning, before the presumed long-term ischemia, and per-conditioning, during long-term ischemia, or as post-conditioning after a long-term ischemia. It is quite safe, non- invasive, inexpensive and easily feasible method. This thesis describes the so far identified molecular mechanisms involved in the development of cardioprotection mediated by remote conditioning.
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The role of endothelin system in the treatment of chronic renal failure
Drábková, Natálie ; Vaněčková, Ivana (advisor) ; Vebr, Pavel (referee)
Chronic kidney disease (CKD) is a life-threatening disease arising as a frequent consequence of diabetes and hypertension. Since it is silent for a long time, it often progresses to end-stage renal disease (ESRD). Managing chronic kidney disease, the prevalence of which is sharply increasing in the last decades due to the ageing of the world population, is thus major health problem. Apart from blockers of renin-angiotensin system, which are used as the "golden standard" in the treatment of CKD due to their antihypertensive and renoprotective effects, other strategies are also applied for the management of this disease. A relatively new class of therapeutics - blockers of endothelin system - seems to be very promising in this field.
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