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Determination of Physico-Chemical Characteristics of Drugs
 Smolová, Eva ; Kubíček, Vladimír (advisor) ; Nováková, Veronika (referee)
Title and author's name Eva Smolová Institution Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Heyrovského 1203, 500 05 Hradec Králové Specialization Pharmacy Title of thesis Determination of the physico-chemical characteristics of drugs Consultant Ing. Vladimír Kubíček, CSc. Number of pages 75 Defended 2014 Keywords Dissociation constant, Potentiometry, Spectrophotometry The aim of the thesis was the determination of dissociation constants of eight potential drugs (synthetized at Department of Pharmaceutical Chemistry and Pharmaceutical Analysis) using potentiometric and UV-VIS spectrophotometric methods. The theoretical part of the thesis is focused preferably to protolytic reactions, pH determination and dissociation constant determination. Utilization of dissociation constants is described in the last paragraph of the theoretical part. The experimental part deals with the description of dissociation constant measurements and processing experimental data. In the final part the results are summarized. Parts of the human body, in which the studied drugs would be found in the neutral form, are given. The obtained results were compared with literary data. Agreement of the most of the results with the literary data is very good.
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