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The role of γc cytokines in the immune system and cancer immunotherapy
Ptáček, Bohumil ; Kovář, Marek (advisor) ; Adkins, Irena (referee)
Cytokines are proteins produced mostly by cells of hematopoietic origin and transduce signals via engaging cell surface receptors on either the cytokine-producing cells (autocrine signaling) or other target cells (paracrine signaling). Common cytokine receptor subunit (γc) cytokines are small glycoproteins belonging to type I cytokines with pleiotropic activities in both the innate and adaptive immune systems. All γc cytokines share a γc receptor subunit in their complete receptors. The first part of this thesis aims to summarize information about the biology of γc cytokines, their receptors, and their role in the immune system and its functions. The second part discusses the use of γc cytokines in cancer immunotherapy, presenting examples of particular γc cytokine therapies, and describes the approaches to improve the pharmacological features of γc cytokines or efficiently combine them with other immunotherapies and anticancer treatments. Keywords: γc cytokine, cytokine receptor, T cell, NK cell, cancer immunotherapy
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