National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
A study of the compressibility and the properties of tablets from the coprocessed dry binder with mannitol for oral disintegrating tablets.
Lešková, Patrícia ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Candidate: Patrícia Lešková Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the diploma thesis: A study of the compressibility and the properties of tablets from the coprocessed dry binder with mannitol for oral disintegrating tablets This thesis deals with the study of directly compressible tableting materials and tablets with Ludiflash® , which was intended for ODT formulation. The effect of three lubricants was evaluated on the properties of tableting materials and tablets. Testing lubricants were magnesium stearate, calcium stearate and sodium stearyl fumarate in concentrations of 0,5 and 1%. Flow properties, compressibility, ejection force, tensile strength and disintegration time of the tablets were tested. Energy profile of compression process was used for the evaluation of compressibility. Lubricants did not improve the flowability of Ludiflash® . The total energy of compression increased with compression force. Its the highest values were at the tableting materials with 0,5% concentration of magnesium stearate and sodium stearyl fumarate, while the lowest values were at the tableting materials with 1% calcium stearate. The values of plasticity decreased with compression force and there was...
A study of the compressibility and the properties of tablets from the coprocessed dry binder with mannitol for oral disintegrating tablets.
Lešková, Patrícia ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Candidate: Patrícia Lešková Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the diploma thesis: A study of the compressibility and the properties of tablets from the coprocessed dry binder with mannitol for oral disintegrating tablets This thesis deals with the study of directly compressible tableting materials and tablets with Ludiflash® , which was intended for ODT formulation. The effect of three lubricants was evaluated on the properties of tableting materials and tablets. Testing lubricants were magnesium stearate, calcium stearate and sodium stearyl fumarate in concentrations of 0,5 and 1%. Flow properties, compressibility, ejection force, tensile strength and disintegration time of the tablets were tested. Energy profile of compression process was used for the evaluation of compressibility. Lubricants did not improve the flowability of Ludiflash® . The total energy of compression increased with compression force. Its the highest values were at the tableting materials with 0,5% concentration of magnesium stearate and sodium stearyl fumarate, while the lowest values were at the tableting materials with 1% calcium stearate. The values of plasticity decreased with compression force and there was...

Interested in being notified about new results for this query?
Subscribe to the RSS feed.