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Study on renal transport of radiopharmaceuticals
Kaňoková, Jana ; Trejtnar, František (advisor) ; Pávek, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Jana Kaňoková Supervisor: Doc. PharmDr. František Trejtnar, CSc. Title of diploma thesis: Study on renal transport of radiopharmaceuticals Radiolabelled receptor-specific peptides from the group of gastrin and bombesin derivatives are currently intensively researched substances in terms of targeting certain tumors. The main limit in their application is the intense renal accumulation and subsequent radiotoxicity. The aim of this experimental study was to determine and then compare the renal uptake of DOTA-bombesin and one of the gastrin derivatives - DOTA-sargastrin labeled with indium-111 and lutetium-177. Moreover, the other goal of this study was to assess the potential role of megalin system in the active endocytosis in the renal accumulation of these substances. Isolated rat kidney cells obtained by the collagenase perfusion method were used as an experimental model. The uptake of studied radiopeptides was further compared with the degree of accumulation of selected comparators with different renal accumulation (99m Tc- DTPA, 99m Tc-MAG3). The results of accumulation studies showed that the accumulation of the labeled derivatives of DOTA-sargastrin in rat kidney cells was...
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Study on renal transport of radiopharmaceuticals
Kaňoková, Jana ; Trejtnar, František (advisor) ; Pávek, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Jana Kaňoková Supervisor: Doc. PharmDr. František Trejtnar, CSc. Title of diploma thesis: Study on renal transport of radiopharmaceuticals Radiolabelled receptor-specific peptides from the group of gastrin and bombesin derivatives are currently intensively researched substances in terms of targeting certain tumors. The main limit in their application is the intense renal accumulation and subsequent radiotoxicity. The aim of this experimental study was to determine and then compare the renal uptake of DOTA-bombesin and one of the gastrin derivatives - DOTA-sargastrin labeled with indium-111 and lutetium-177. Moreover, the other goal of this study was to assess the potential role of megalin system in the active endocytosis in the renal accumulation of these substances. Isolated rat kidney cells obtained by the collagenase perfusion method were used as an experimental model. The uptake of studied radiopeptides was further compared with the degree of accumulation of selected comparators with different renal accumulation (99m Tc- DTPA, 99m Tc-MAG3). The results of accumulation studies showed that the accumulation of the labeled derivatives of DOTA-sargastrin in rat kidney cells was...
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Unit Trust Evaluation in Light of Multiple-Criteria Decision Making
Kaňoková, Jana ; Kuncová, Martina (advisor) ; Fíglová, Zuzana (referee)
The target of this work is to evaluate the unit trusts in light of the multiple-criteria decision making. The unit trusts are divided into the groups according to the investor categories: unit trusts with conservative, balanced and aggressive portfolio. The unit trusts were lined up by the medium of the multiple-criteria decision making methods (PRIAM, ORESTE, MAPPAC) and it is also made an analysis why have each of the methods chosen the particular unit trust in the group as the best compromise variant.
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