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Migration of pharmaceuticals in soil systems
Janebová, Denisa ; Pekař, Miloslav (referee) ; Klučáková, Martina (advisor)
The increasing use of drugs leads to their frequent occurrence in the environment, which poses a risk not only because it can lead to the proliferation of antibiotic-resistant bacterial strains, but also because it can threaten human health. Therefore, this work focuses on the issue of the occurrence and behaviour of two antibiotics in soil, specifically tetracycline and sulfamethoxazole. Due to the presence of soil organic matter, it is believed that the soil can partially prevent the spread of drugs that enter the environment. The diploma thesis involved conducting diffusion experiments in soil columns under real conditions to determine the effective diffusion coefficients of tetracycline and sulfamethoxazole in three extraction agents. Sorption and desorption processes were also conducted in the individual layers of the soil column. The concentrations of the leachates were measured using UVVis spectrometry and liquid chromatography, while FTIR spectrometry was used to confirm the presence of the bound drug in the soil column.
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Transport of pharmaceuticals in soil systems
Janebová, Denisa ; Enev, Vojtěch (referee) ; Klučáková, Martina (advisor)
Drugs have a negative effect on nature. If they do not degrade in wastewater treatment plants, they can contaminate lakes, rivers and even drinking water. However, the soil contains soil organic matter, which has chelating properties and can prevent the migration of the drug. The aim of this bachelor thesis was to map the transport of the selected drug in the soil column and try to determine its diffusivity. Sulfapyridine was chosen for transport. Sulfapyridine belongs to a group of sulfonamide antibiotics that are often detected in the environment. It is mainly used in veterinary medicine to treat various infections. The partial goal was to describe the basic properties of the soil depending on the depth of the soil layer. The drug concentration profile in the soil column was determined by UVVIS spectrometry in soil extracts. The following reagents were used for leaching: distilled water, as a pure solvent without the presence of other substances, tap water as a model reagent replacing the soil solution and magnesium chloride solution, which is used for soil extracts of freely moving and ionically bound substances in the soil.
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Transport of pharmaceuticals in soil systems
Janebová, Denisa ; Enev, Vojtěch (referee) ; Klučáková, Martina (advisor)
Drugs have a negative effect on nature. If they do not degrade in wastewater treatment plants, they can contaminate lakes, rivers and even drinking water. However, the soil contains soil organic matter, which has chelating properties and can prevent the migration of the drug. The aim of this bachelor thesis was to map the transport of the selected drug in the soil column and try to determine its diffusivity. Sulfapyridine was chosen for transport. Sulfapyridine belongs to a group of sulfonamide antibiotics that are often detected in the environment. It is mainly used in veterinary medicine to treat various infections. The partial goal was to describe the basic properties of the soil depending on the depth of the soil layer. The drug concentration profile in the soil column was determined by UVVIS spectrometry in soil extracts. The following reagents were used for leaching: distilled water, as a pure solvent without the presence of other substances, tap water as a model reagent replacing the soil solution and magnesium chloride solution, which is used for soil extracts of freely moving and ionically bound substances in the soil.
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