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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Effect of diet on the development of liver damage of non-alcoholic steatohepatitis in mice
 Hemmerová, Amálie ; Rathouská, Jana (advisor) ; Němečková, Ivana (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Bioanalytical laboratory diagnostics in healthcare Diploma thesis Author: Bc. Amálie Hemmerová Supervisor: PharmDr. Jana Rathouská, Ph.D. Title: Effect of diet on the development of liver damage of non-alcoholic steatohepatitis in mice This thesis deals with the study of non-alcoholic steatohepatitis (NASH), which is considered to be a very serious chronic liver disease. Non-alcoholic steatohepatitis is an advanced form of NAFLD (non-alcoholic fatty liver disease) and is characterized by the presence of hepatic steatosis and inflammation. NASH can be followed by complications such as liver cirrhosis or hepatocellular carcinoma. For NASH research, the first thing to do is to choose the right animal model and diet. In this regard, the CDAA-HFD dietary model, which was also specified in this work, appears to be a very effective model for the study of NASH and hepatocellular carcinoma. The aim of the present study was to investigate the effect of that dietary regimen on the development of hepatic damage of the character of non-alcoholic steatohepatitis. For this purpose, selected parameters of liver fibrosis were monitored in mice in which the mentioned damage was induced by the dietary regimen. The...
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Helicobacter pylori a and current knowledge in treatment
 Hemmerová, Amálie ; Vejsová, Marcela (advisor) ; Janďourek, Ondřej (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Medical Laboratory Technician Bachelor's thesis Author: Amálie Hemmerová Supervisor: Mgr. Marcela Vejsová, Ph.D. Title: Helicobacter pylori and current knowledge in treatment This work is based on the pathogenic Helicobacter pylori which plays an important role in many gastroduodenum diseases. The aim of this work is summarizing the information of the Helicobacter pylori and presenting some actual knowledge of its treatment. Helicobacter pylori is a gram-negative microaerophilic spiral bacillus that lives under the layer of mucosae, area of neutral pH, and it causes an inflammatory changes on gastric epithelium. Half of the population worldwide is infected. It is important to find a suitable therapy for succesful treatment. Until recently the first-line treatment was the standard triple combination clarithromycin/metronidazole, amoxicilline and PPI. However the effectiveness of this combination has been reduced in the most countries to a level lower than recommended eradication rate (< 80 %). The cause of the failure was resistence to clarithromycin/metronidazole. Bismuth quadruple therapies are effective in the most countries. They are used as the first-line treatment and also as rescue therapy...
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