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Calculation of elasticity and plasticity of microcrystalline cellulose Ceolus KG 802
Filipčíková, Michaela ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Calculation of Elasticity and Plasticity of Microcrystalline Cellulose Ceolus KG 802 Mgr. Michaela Filipčíková, 2007 Microcrystalline cellulose is an important pharmaceutical excipient. Ceolus KG 802 is one type of microcrystalline cellulose, which reduces addition amount of pharmaceutical powders. It also facilitates tableting of pressure - sensitive drugs such as enzymes, antibiotics etc. The aim of this Rigorous thesis was the calculation of elasticity and plasticity of microcrystalline cellulose Ceolus KG 802. The plasticity was determined from graphs showing the decreasing trend of force on the time. We used three methods. First one was based on identification of maximum and minimum forces, second used "one-parameter" evaluation of curve from graphs showing the relation of the force to the time and third "three-parameter" evaluation of these curves. We also determined Young's modulus which characterizes elasticity of system and equals 100,0287 MPa. We were able to distinguish two sections of the curve from graphs showing the relation of the plasticity to the compression force. These sections characterize particular phases of compression and changes of system. We distinguished phase of precompression, then phase of elastic and plastic deformation. This rigorous thesis deals with confrontation...
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Determination of Residual Plasticity in Tablets from Microcrystalline Cellulose
Filipčíková, Michaela ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Determination of Residual Plasticity in Tablets from Microcrystalline Cellulose Michaela Filipčíková, 2007 Abstract Microcrystalline cellulose is an important pharmaceutical excipient. Ceolus KG 802 is one type of microcrystalline cellulose. The aim of this Diploma thesis was the determination of plasticity in tablets from microcrystalline cellulose (Ceolus KG 802) and to valuate the influence of compression force on plasticity. The influence of both a type of microcrystalline cellulose and different compression conditions on the second section of the graph curve showing the relation of the plasticity to the compression force was investigated as well. Test Xpert V9.01, Microsoft Excel and Origin Professional 7.5 were used for processing compaction data. The plasticity was determined from graphs showing the decreasing trend of force on the time. We used methods which were based on identification of maximum and minimum forces and then method which was based on valuation of the area. Considering to uncertainty in the scope of plasticity is the plasticity considered as a residual one. We found that these three methods gave comparable results. We were able to distinguish two sections of the curve from graphs showing the relation of the plasticity to the compression force. The first section characterizes the...
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Calculation of elasticity and plasticity of microcrystalline cellulose Ceolus KG 802
Filipčíková, Michaela ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Calculation of Elasticity and Plasticity of Microcrystalline Cellulose Ceolus KG 802 Mgr. Michaela Filipčíková, 2007 Microcrystalline cellulose is an important pharmaceutical excipient. Ceolus KG 802 is one type of microcrystalline cellulose, which reduces addition amount of pharmaceutical powders. It also facilitates tableting of pressure - sensitive drugs such as enzymes, antibiotics etc. The aim of this Rigorous thesis was the calculation of elasticity and plasticity of microcrystalline cellulose Ceolus KG 802. The plasticity was determined from graphs showing the decreasing trend of force on the time. We used three methods. First one was based on identification of maximum and minimum forces, second used "one-parameter" evaluation of curve from graphs showing the relation of the force to the time and third "three-parameter" evaluation of these curves. We also determined Young's modulus which characterizes elasticity of system and equals 100,0287 MPa. We were able to distinguish two sections of the curve from graphs showing the relation of the plasticity to the compression force. These sections characterize particular phases of compression and changes of system. We distinguished phase of precompression, then phase of elastic and plastic deformation. This rigorous thesis deals with confrontation...
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Determination of Residual Plasticity in Tablets from Microcrystalline Cellulose
Filipčíková, Michaela ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Determination of Residual Plasticity in Tablets from Microcrystalline Cellulose Michaela Filipčíková, 2007 Abstract Microcrystalline cellulose is an important pharmaceutical excipient. Ceolus KG 802 is one type of microcrystalline cellulose. The aim of this Diploma thesis was the determination of plasticity in tablets from microcrystalline cellulose (Ceolus KG 802) and to valuate the influence of compression force on plasticity. The influence of both a type of microcrystalline cellulose and different compression conditions on the second section of the graph curve showing the relation of the plasticity to the compression force was investigated as well. Test Xpert V9.01, Microsoft Excel and Origin Professional 7.5 were used for processing compaction data. The plasticity was determined from graphs showing the decreasing trend of force on the time. We used methods which were based on identification of maximum and minimum forces and then method which was based on valuation of the area. Considering to uncertainty in the scope of plasticity is the plasticity considered as a residual one. We found that these three methods gave comparable results. We were able to distinguish two sections of the curve from graphs showing the relation of the plasticity to the compression force. The first section characterizes the...
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