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The Influence of Selective Ventilation on the Concentration of Antibiotics in Lung Tissue - Microdialysis Study
Děrgel, Martin ; Manďák, Jiří (advisor) ; Šantavý, Petr (referee) ; Brát, Radim (referee)
Mini-invasive surgical techniques are currently replacing the standard open techniques. The advantages of these techniques consist of minimal surgical stress (small surgical wounds, integrity of the rib cage, better wound healing, and shorter time spent on mechanical ventilation), quicker convalescence periods and a return to ordinary life. The delicate and precise operating techniques in mini-invasive procedures require long- term preparation and training of the whole surgical team and a good visualization of the operation field with the aid of specialized surgical and optical instruments. In cardiac surgical patients, selected surgical techniques are carried out via a thoracotomy incision, preferably with selective ventilation, i.e., "one lung ventilation" with a collapsed lung allowing for better visualization. This method assures comfort to the operating surgeon, albeit this can lead to complications such as atelectasis and pneumonia. The administration of antibiotics minimizes the perioperative infection risk before every invasive cardiac procedure. Interstitial microdialysis is the preferred method to ascertain if the administered prophylactic antibiotic penetrates the pulmonary tissue. Microdialysis is a mini-invasive method that monitors exogenic and endogenic molecules in the extracellular...
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