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Modulation of mitochondrial dynamics in Parkinson's disease
 Baďurová, Marie ; Doležal, Martin (advisor) ; Zimčík, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Marie Ba urová Supervisor: Prof. Doutor Jorge Miguel de Ascenção Oliveira Prof. PharmDr. Martin Doležal, Ph.D. Co-advisor: Dr. Brígida Ribeiro Pinho Title of diploma thesis: Modulation of mitochondrial dynamics in Parkinson's disease Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the world. How to cure this illness still remains unknown. There are only means by which help to reduce Parkinson-like symptoms. Among pathological mechanisms that are associated with PD belong mutations of some genes (such as -synuclein, Parkin, PINK1) and there is also an association between mitochondrial dysfunction and PD. It was previously shown that excessive mitochondrial-dependent apoptosis can lead to neurodegeneration. The aim of our research was to test the drug mdivi-1 (mdivi), which acts as mitochondrial division inhibitor and prevents mitochondria-dependent apoptosis. Mdivi-1 selectively targets and inhibits the dynamin related protein 1 (DRP1), which mitochondria need in division and also blocks releasing of pro-apoptotic mediator cytochrome c by inhibition of outer membrane permeabilization. We wanted to test its concentration-dependent effects...
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