|
| |
|
|
Education of patients with hepatitis C in selected high - risk groups.
Gluzová, Jana ; Holubová, Jana (advisor) ; Řehák, Vratislav (referee)
BACKGROUND: Chronic hepatitis C is an infectious viral disease that is currently the cause of significant morbidity and mortality in our country and worldwide. The group most at risk of this disease are injecting drug users, where it is particularly important to support motivation and increase adherence in treatment. One way to do this is to properly and thoroughly educate patients. AIMS: The main objective of the research is to investigate the education of respondents in the treatment of viral hepatitis C by means of a questionnaire survey. A partial goal is to create a proposal for the education of nurses in the hepatitis clinic. METHODS: For the quantitative research, the questionnaire method was used. The questionnaire was designed for patients of a private hepatological clinic. RESULTS: All patients were educated about the treatment of viral hepatitis C, but different subjects were covered. The content of education was sufficient for 62 % patients, for 62 % was the education understandable. A conversation with the doctor was an ideal way of education for 68 % respondents. Upon another visit to the hepatological clinic, reeducation was done by a nurse in 70 % cases. Health education took 70 % of respondents within 30 minutes, of which 24 % only took 5-10 minutes. CONCLUSIONS: All patients...
|
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
|
Construction of a genetically detoxified Bordetella pertussis strain to develope a new generation of whole-cell vaccine
Bočková, Barbora ; Holubová, Jana (advisor) ; Seydlová, Gabriela (referee)
Bordetella pertussis is a strictly human pathogen colonizing the upper respiratory tract, causing a respiratory disease known as whooping cough or pertussis. The introduction of whole-cell vaccines and acellular vaccines, resulted in a significant reduction in the incidence of disease and reduce the fatalities associated with infection. However, epidemiological data show a significant increase in the incidence of the disease in recent decades. The increasing incidence is mainly attributed to the transition from the whole- cell vaccine to an acellular vaccine. Based on research from recent years has shown that acellular vaccines have many drawbacks, and it is therefore necessary to change the vaccination strategy. One possible solution to the situation is the development of a new generation of whole-cell vaccines with reduced reactogenicity. The new whole-cell vaccine was prepared by a genetically modified B. pertussis strain. B. pertussis was modified using allelic exchange to develop strain encoding enzymatically inactive pertussis toxin, modified lipid A and lacking dermonecrotic toxin. This combination of genetic modifications in mice led to a decrease in reactogenicity test vaccine in vivo. In case of intranasal infection whole-cell vaccine containing genetically modified strain is providing...
|
|
| |
guest ::
