|
|
Synthesis of azaphthalocyanines substituted with moieties derived from trimesic acid
Kollár, Jan ; Zimčík, Petr (advisor) ; Roh, Jaroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Author: Jan Kollár Supervisor: Doc. PharmDr. Petr Zimčík, PhD. Title of diploma thesis: Synthesis of azaphthalocyanines substituted with moieties derived from trimesic acid Aim of this work was a synthesis of new photosensitizers from the group of water- soluble azaphthalocyanines (AzaPc) with future potential to be used in PDT. The starting compound for synthesis, trimesic acid, was esterified by ethanol and the triester was partially hydrolysed to mono carboxylic acid. Subsequently, the carboxyl group was selectively reduced to hydroxyl followed by oxidation to aldehyde. Benzoin condensation of this aldehyde gave acyloin that was oxidized to tetraethyl 5,5'-oxalyldiisophthalate. Substituted pyrazine-2,3-dicarbonitrile, a precursor for AzaPc, was obtained by condensation of diaminomaleonitirile with this vicinal diketon. Cyclotetramerization using magnesium butoxide as initiator gave magnesium(II) AzaPc substituted with sixteen butoxycarbonyl groups. Magnesium complexes were converted to metal-free AzaPc in acidic medium and then to zinc(II) AzaPc by reaction with anhydrous zinc acetate. Tetraethyl 5,5'-oxalyldiisophthalate was also hydrolyzed to diketon with four free...
|
|
|
Individual production of caravan
Kollar, Jan ; Lachnit, František (advisor) ; Kotek, Martin (referee)
The topic of this thesis is individual construction of the O1 category caravan on
mass produced cargo trailer chasiss. For simplifying administrative processes, the whole
construction is done as a rebuild. Thesis is about workflow of construction, legislative
requirements and documents that need to be present to all neccesary autorities. In thesis the
whole idea of building a caravan is covered. It starts from documentation, then buing of mass
produced chasiss is described, the build itself is described and in the end there is information
about registering of completed caravan according to czech law 56/2001 Sb. - o podmínkách
provozu vozidel na pozemních komunikacích (law about requirements for road driven
vehicles). In the thesis the choice of ideal mass produced chasiss is described, materials used
for construction are defined and necessary homologated parts needed for legal registration are
labeled.
|
guest ::
