Vztah neurokognitivní rezervy ke kognitivnímu výkonu u pacientů s první atakou onemocnění schizofrenního spektra

Knížková, Karolína

The main aim of this work was to examine cognitive (CR) and brain reserve (BR) in individuals diagnosed with first-episode schizophrenia spectrum disorders and to compare their impact on cognitive performance, clinical characteristics, and quality of life. CR refers to the ability to optimize or maximize performance through differential recruitment of brain networks, whereas BR is related to structural brain characteristics that provide passive protection against pathology. In schizophrenia, both CR and BR might influence cognition and serve as predictors for cognitive, clinical and functional outcomes of patients. To measure CR, we used a questionnaire designed for people with severe mental health disorders called "Cognitive Reserve Assessment Scale in Health" and for BR, we selected a total gray matter volume adjusted to sex and age. Participants were patients (n = 51) diagnosed with a first-episode schizophrenia spectrum disorder and healthy controls (n = 58). All participants completed clinical, neuropsychological, and neuroimaging assessments at baseline and at a one-year follow-up. Cognitive performance was evaluated with a comprehensive neuropsychological battery assessing five cognitive domains. We found a moderate positive correlation between CR and BR. At baseline, CR significantly...

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