Optimalizace přípravy nanonosičů inhibitorů Janusových kináz

Košutová, Martina

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Supervisor: PharmDr. Ondřej Holas, Ph.D. Consultant: Mgr. Petra Máslová Student: Martina Košutová Title of thesis: Optimization of preparation of nanocarriers of Janus kinase inhibitors Rheumatoid arthritis is a chronic autoimmune inflammatory disease characterized by persistent synovial inflammation and progressive joint destruction. Janus kinase inhibitors (JAKi) are selective synthetic disease-modifying antirheumatic drugs, but their systemic administration may be associated with several adverse effects, such as infections, thromboembolic events and increased risk of malignancies. The aim of this study was to prepare polymeric nanoparticles (NPs) based on poly(lactic-co- glycolic acid) (PLGA) for the encapsulation of the selective JAKi filgotinib. The NPs were prepared using both nanoprecipitation and emulgation-solvent evaporation methods. Polymeric NPs may accumulate in inflamed tissue, due to passive targeting known as the ELVIS effect, while prolonging a relatively short biological half-life of the filgotinib. The prepared NPs were characterized in terms of particle size and polydispersity index using dynamic light scattering, while the encapsulation efficiency and drug loading were...

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