Charakterizace lipozomů s nanočásticemi stříbra

Eškutová, Soňa

Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Mentor: Mgr. Monika Smékalová, Ph.D. Student: Soňa Eškutová Title of thesis: Characterization of liposomes with silver nanoparticles Silver nanoparticles (AgNP) are increasingly utilised in the world of medicine due to their antimicrobial properties. Liposomes are primarily used to enhance the solubility of lipophilic drugs and for drug delivery systems. The aim of this thesis was to synthesize a nanoparticle system of AgNP encapsulated in liposomes (LipoAgNP). The LipoAgNP were characterised in terms of size, PDI and ζ-potential and were compared with AgNP and liposomes. Influence of temperature and pH on LipoAgNP was also investigated. The stability of stored liposomal system is highly influenced by temperature. The greatest level of unstability of stored liposomes and LipoAgNP was shown at the highest temperature (50 řC), in which fluctuations were observed in size, PDI, and ζ-potential. Storing liposomal system in high temperatures could result in degradation of the lipososmal membrane. Storing liposomes and LipoAgNP at 25 řC exhibits stability in the short term. Storing liposomes and LipoAgNP at a temperature of 4 řC showed the best results. The envirometal pH greatly affects the stability of...

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