Disoluční a permeační studie in situ filmů pro topickou aplikaci léčiv

Štálniková, Aneta

CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Mentor: PharmDr. Eva Šnejdrová, Ph.D. Student: Aneta Štálniková Title of Thesis: Dissolution and permeation studies of in situ films for topical drug delivery The aim of this diploma thesis was to develop and experimentally evaluate in situ forming PLGA films as carriers for the topical administration of salicylates: methyl salicylate (MS), salicylic acid (SA) and cannabidiol (CBD) using dissolution and permeation tests. The film- forming systems (FFS) were prepared by the film casting method, based on branched and linear PLGA polymers. The in situ films were formed through the evaporation of ethyl acetate, with their properties being modified by the addition of methyl salicylate and ethyl pyruvate as plasticizers. This step led to improved elasticity of the resulting films and successfully eliminated the lag-phase of CBD release during the first 24 hours. Dissolution profiles of the drugs, studied in phosphate-citrate buffer at pH 5.5 and 32 řC, demonstrated that the choice of the branched PLGA/A polymer led to a deceleration of salicylate release and the achievement of zero-order kinetics compared to the linear polymer. Permeation tests performed in Franz diffusion cells using the Strat-M® membrane...

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