Original title: Role of Ribokinase in Immunometabolism of Drosophila melanogaster
Authors: SYSEL, Jakub
Document type: Bachelor's theses
Year: 2025
Language: eng
Abstract: This thesis explores the role of ribokinase (RBKS) in the immunometabolism of Drosophila melanogaster, with particular focus on its potential involvement in the newly proposed gluconate ribose pathway (GRP). Using genetic tools, RBKS mutants were generated and tested for immune and metabolic phenotypes. Preliminary immune assays, including lamellocyte counts and resistance to parasitoid wasp infection, suggest a role of RBKS in immunity. Mass spectrometry revealed metabolic changes, including altered nucleotide synthesis and accumulation of 2 dehydrogluconate, a key GRP intermediate. These findings support a metabolic function of RBKS and highlight the GRP as a potential link between carbohydrate metabolism and immune function in Drosophila.
Keywords: Drosophila; immunity; metabolism; ribokinase
Citation: SYSEL, Jakub. Role of Ribokinase in Immunometabolism of <i>Drosophila melanogaster</i>. České Budějovice, 2025. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/76041

Permalink: http://www.nusl.cz/ntk/nusl-695278


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Bachelor's theses