Original title: The role of phospholipid remodeling in Trypanosoma brucei
Authors: ŠÁNKOVÁ, Gabriela
Document type: Bachelor's theses
Year: 2024
Language: eng
Abstract: The research goal is to identify cardiolipin remodeling enzyme. For the purpose of my study, we chose two proteins: ALCAT1 and delta 12 desaturase. ALCAT1 will be epitope-tagged to determine its subcellular localization in T. brucei. Its expression will be depleted by RNA interference to see if there is any effect on the physiology and morphology of the mitochondrion. Delta 12 desaturase may be involved in the remodeling of all phospholipids not just cardiolipins. To see if there is any effect on the stage differentiation and growth we will deplete the expression of delta 12 desaturase by gene knockout.
Citation: ŠÁNKOVÁ, Gabriela. The role of phospholipid remodeling in <i>Trypanosoma brucei</i>. České Budějovice, 2024. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/73261

Permalink: http://www.nusl.cz/ntk/nusl-694986


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Bachelor's theses