Original title: Syntéza modifikovaných pyrazolopyrimidinových ribonukleosidů s potenciální biologickou aktivitou
Translated title: Synthesis of modified pyrazolopyrimidine ribonucleosides with potential biological activity
Authors: Klapková, Magdalena ; Hocek, Michal (advisor) ; Baszczyňski, Ondřej (referee)
Document type: Bachelor's theses
Year: 2025
Language: cze
Abstract: [cze] [eng]
V této bakalářské práci byly připraveny 4 modifikované pyrazolopyrimidinové ribonukleosidy s potenciální biologickou aktivitou. Syntéza obsahovala glykosylaci, hydrogenaci, diazotační chlorodeaminaci a následně byl proveden Suzuki-Miyaura cross-coupling. Na závěr byly odstraněny chránící skupiny nukleosidů. Bude testována schopnost těchto ribonukleosidů inhibovat MtbADK a také jejich protinádorová aktivita. Klíčová slova: pyrazolopyrimidiny, nukleosidy, Suzuki-Miyaura cross-coupling, 7-deazapuriny, biologická aktivita A series of 4 pyrazolopyrimidine nucleosides with potential biological activity was prepared in this bachelor thesis. The synthesis consisted of glycosylation, hydrogenation, diazotation and subsequently Suzuki-Miyaura cross-coupling was performed. Finally, the protecting groups were removed. The ability of those ribonucleosides to inhibit MtbADK and their anticancer activity will be tested. Key words: pyrazolopyrimidines, nucleosides, Suzuki-Miyaura cross-coupling, 7-deazapurines, biological activity
Keywords: biological activity; nucleosides; pyrazolopyrimidines; Suzuki-Miyaura cross-coupling,7-deazapurines; biologická aktivita; nukleosidy; pyrazolopyrimidiny; Suzuki-Miyaura cross-coupling,7-deazapuriny

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/204122

Permalink: http://www.nusl.cz/ntk/nusl-690318


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Bachelor's theses