Hledání cirkulujících biomarkerů charakterizujících časnou axiální spondylartritidu a její progresi

Mocová, Klára

Axial spondyloarthritis (axSpA) is a chronic autoimmune disease primarily affecting the spine and sacroiliac joints. It presents with chronic back pain, sacroiliitis, arthritis, and other skeletal and extra-skeletal inflammatory symptoms. This inflammation can lead to irreversible structural changes and damage to the spine resulting in reduced mobility, decreased quality of life, and chronic disability. The risk of radiographic progression is hard to predict in the early stages of the disease which can lead to long delays in establishing a patient's diagnosis and disease classification. Early biomarkers that could indicate patients with a higher risk or in early stages of structural progression could save these patients years of pain and possible lasting damage to the spine. We analyzed the proteomic profile of blood plasma and microRNA expression in PBMC samples from patients with axSpA, collected before they experienced structural progression on spine, and we compared the protein and microRNA levels to those of patients who did not experience such progression. After a statistical analysis, six candidate protein biomarkers and fifteen candidate microRNAs were chosen for further validation. We analyzed the candidates' association with structural progression on spine and their predictive ability. Although we...

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