Original title: Understanding Immune Responses in Basal Vertebrates: On Immune Functions of Erythrocytes and Immunological Memory Mediated by B Cells
Authors: MAJSTOROVIC, Jovana
Document type: Doctoral theses
Year: 2025
Language: eng
Abstract: Multicellular organisms utilize complex immune defenses, integrating both humoral and cellular mechanisms to maintain immunity and fight pathogens. Invertebrates rely on innate immunity with fixed responses, while vertebrates have adaptive immunity, which allows for quicker responses to previously encountered pathogens. Historically, innate immunity and adaptive immunity were viewed as separate domains, with memory associated solely with vertebrates; however, recent studies reveal that innate immunity can also exhibit memory-like traits, challenging the established distinctions. Immunological memory systems in basal vertebrates differ significantly from those in mammals, as they rely primarily on innate immune mechanisms and primitive adaptive responses, while specialized B cell-based adaptive systems represent an innovation which evolved into the highly specialised and long-lasting adaptive immunity of mammals. This thesis explores immune mechanisms of basal vertebrates against bacterial and parasitic infections, emphasizing the poorly explored role of nucleated erythrocytes in innate immunity and the contribution of B cells to lasting immunological memory, in teleost fishes. This research underscores the interconnectedness of various immune components and the universal nature of immunological memory across vertebrates.
Keywords: adaptive immunity; B cells; basal vertebrates; immunological memmory; red blood cells
Citation: MAJSTOROVIC, Jovana. Understanding Immune Responses in Basal Vertebrates: On Immune Functions of Erythrocytes and Immunological Memory Mediated by B Cells. České Budějovice, 2025. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/77690

Permalink: http://www.nusl.cz/ntk/nusl-688471


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses