Nové způsoby léčby poruch pánevního dna

Macková, Kateřina

We aimed to test selected novel treatment modalities for pelvic floor dysfunctions and genitourinary syndrome of menopause. Both conditions are common in female, they negatively affect their quality of life, and current treatment options are not optimal. We started our research with an extensive literature search. First, we summarized the information on animal models for, and the utility they may have in the investigation of the pathophysiology of POP and novel therapies. We systematically searched 7426 articles from which 51 fulfilled the inclusion criteria. From all screened animals, only the non-human primate develops POP spontaneously, however their use is controversial. We concluded that many studies have methodological shortcomings and lack standardization in reporting outcomes. Also, several other animals can be used as a model of surgery for POP, each of them with different purposes. For our later research we chose the rat model to simulate POP repair with synthetic mesh. We also systematically reviewed the literature on the objective effects of non-ablative Er:YAG LASER on the skin and vaginal wall. We identified 7187 articles of which we included 15 in our review, including four that tested Er:YAG LASER on vaginal tissue. Er:YAG LASER energy induces measurable changes in the deeper skin...

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