Original title: Role of IDGFs and adenosine signaling in cell survival and energy homeostasis
Authors: BROŽ, Václav
Document type: Doctoral theses
Year: 2017
Language: cze
Abstract: Two groups of growth regulators were described in Drosophila imaginal disc cell culture Cl.8+. Imaginal disc growth factors (IDGFs) belonging to chitinase-like protein family of carbohydrate binding proteins and Adenosine deaminase-related growth factors (ADGFs), which are active adenosine deaminases influencing homeostasis of key cellular metabolite adenosine. The functions of two of the IDGFs, as well as the effects of extracellular adenosine and its receptor were studied primarily in in vitro cell culture. Our results supported their roles in the regulation of cell survival and energy homeostasis especially in imaginal disc cells. Both the IDGFs and adenosine also play important roles in organismal responses to stress and infection and may interact in vivo.
Keywords: adenosine; cell culture; chitinase like proteins; deoxyadenosine; Drosophila; imaginal disc cells; insulin; mitochondrial polarity; adenosine; cell culture; chitinase like proteins; deoxyadenosine; Drosophila; imaginal disc cells; insulin; mitochondrial polarity
Citation: BROŽ, Václav. Role of IDGFs and adenosine signaling in cell survival and energy homeostasis. České Budějovice, 2017. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/18136

Permalink: http://www.nusl.cz/ntk/nusl-358402


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses