National Repository of Grey Literature 257 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Heat treatment of ductile iron
Vávrová, Veronika ; Ostratický, Marek (referee) ; Bořil, Petr (advisor)
The bachelor thesis is focused on heat treatment and influence on the structure and properties of ductile iron. In the first part there is a description of the basic properties of ductile iron. Then the various types of heat treatment are presented. There is an experiment included focused on ferritisation annealing and its influence on the structure.
The function of ClpX chaperone in bacteria
Kýr, Jan ; Balíková Novotná, Gabriela (advisor) ; Šiková, Michaela (referee)
Intracellular proteolysis is an essential regulatory process that affects cellular physiology. Since proteolysis destroys proteins irreversibly, this process must be strictly controlled. The AAA+ proteins are the key factors in regulated proteolysis in bacteria. These proteins consist of two functional domains, the AAA+ chaperone domain and the protease domain. One particular group of these AAA+ protein is the Clp protein family. Functional domains of the Clp family are formed by seperate proteins. The hexameric unfoldase ClpX is a member of this protein family. This unfoldase can interact with the highly conserved ClpP protease to form a ClpXP proteolytic complex. This proteolytic complex utilizes the energy of ATP binding and hydrolysis to unfold and translocate the specifically tagged substrate into the ClpP degradation chamber. Substrate recognition is mediated by the binding of ClpX to short unstructured sequences called degradation tags. ClpX recognizes several degradation tags, but the most important one is recognition of the ssrA degradation tag, which is the output of the tmRNA ribosome rescue system. Although ClpX interacts with ClpP, it affects a variety of cellular processes such as the expression of virulence factors or the adaptation to stress factors, ClpX can work independently of...
Design of sustainable urban structure of the 21st century in the Czech Republic
Boháčová, Denisa ; Erben, Adam (referee) ; Pavlovský, Tomáš (advisor)
This thesis is solving the design of a sustainable urban structure of the 21st century in Brno, in the area of Kasárna in Černá pole. The thesis is trying to create a neighborhood that would serve not only to the needs of the millennials, but of every generation. It is trying to build a city for the people. I am designing the new development as a lively, diverse and flexible neighborhood which considers the history of the area. I am conserving its rectangular shape in the urban footprint. I am designing a city with clearly defined public spaces. I am opening the neighborhood to the public and therefor allow it to newly connect with neighboring districts. The goal of the design is to create a modern neighborhood that will function as a new subcenter of the city of Brno.
Study of air-entraining admixtures in alkali-activated materials
Kiripolský, Tomáš ; Koplík, Jan (referee) ; Kalina, Lukáš (advisor)
Air entraining admixtures are surfactants, that are commonly used in Portland cement materials, because they form and stabilize small air bubbles distributed in the binder, thereby changing the pore size distribution. The aim of these additives is to increase the durability of the cured binder, especially in climatic conditions, where it must withstand low temperatures, and simultaneously improving the workability in the plastic state. The effect of air entraining admixtures in alkali-activated slag was studied for certain properties. Air entraining admixtures were able to entrain the air in the alkali-activated matrix, they changed the pore size distribution, which resulted in a reduction in capillary pressure in the porous complex, and there was a reduction of shrinkage under autogenous conditions, respectively. The improvement of workability is certainly also positive, but on the other hand there has been a bad effect on flexural strength and compressive strength. The morphology of the air entrained binder was observed by scanning electron microscopy, and simultaneously the effect of air entrained admixtures on hydration was observed by isothermal calorimetry.
Structural NMR studies of protein complexes
Hexnerová, Rozálie ; Veverka, Václav (advisor) ; Hrabal, Richard (referee) ; Hlouchová, Klára (referee)
Protein-protein interactions are involved in various biological processes and detailed characterization of their structural basis by the means of structural biology is often instrumental for rigorous understanding of underlying molecular mechanisms. This information is important not only for fundamental biology but also plays an important role in search for sites amenable for therapeutic intervention. Nuclear magnetic resonance spectroscopy is alongside X-ray crystallography and single-particle cryo-electron microscopy one of the key high-resolution techniques in structural biology. Although its applicability to larger systems has a well-known physical limit, it offers unique capabilities in addressing highly dynamic or inherently heterogeneous systems. In this doctoral thesis, the solution-based NMR approach was used for detailed structural characterization of selected biologically important proteins and their complexes that provided important insights into their biological roles. In three distinct projects, I (i) studied the relationship between the structural effects of particular modifications in the insulin-like growth factor II (IGF-II) and their selectivity to the insulin axis receptors; (ii) the specific binding mechanism of the SH3 domain from the Crk-associated substrate (CAS); (iii) and...
Development and structure of crime in the Czech Republic
Trnková, Michaela ; Gřivna, Tomáš (advisor) ; Bohuslav, Lukáš (referee)
Development and structure of crime in the Czech Republic Abstract This thesis analyses the development and structure of criminality in the Czech Republic in the period 2009 - 2018. The main source of information for this thesis are the statistics of Police of the Czech Republic. The aim of the thesis is to analyse current distribution of criminality, its development and to find out its driving forces. The thesis consists of four chapters. In the first chapter, the basic terminology is defined; especially the terms defining main properties of criminality, information sources on criminality and the issues of credibility of statistical data. In the second chapter, the structure of criminality in the Czech Republic in 2018 is analysed. A general overview is presented here, followed by analysis of various types of criminality. Information on criminality are analysed from the perspective of the criminality extent, its clear-up rate, geographical distribution, person of the perpetrator and extent of damage. In the third chapter, the development of criminality in the Czech Republic in the period 2009 - 2018 is examined. The data are analysed in a similar way (as the data in the chapter two). Last but not least there are mentioned some selected specific values, which have been commented separately. The thesis...
Liminality and career termination among professional ice-hockey players
Neuman, Michal ; Numerato, Dino (advisor) ; Háková, Lucie (referee)
The bachelor thesis deals with the topic of termination of professional ice-hockey career. In particular, it focuses on the period of one's life, which comes after the termination or the decision about the termination of the career. It uses the concept of liminality, which allows focussing on the transition from the sport to post-sport life. Within the analysis, 6 semi- structured qualitative interviews have been done with the former professional ice-hockey players. Those were chosen for different characteristics, for the sample to be miscellaneous. In the transition period, the bachelor thesis focuses on the manifestations of liminality in particular. Those are for example the ambiguity of the individual, the anti-structure, the revaluation, rethinking one's self and the society and the experimenting with the new possibilities, which come to light in this phase of transition. The entry to the new social structure is also dealt with in this thesis. The involvement within the new structure is viewed by the concept of resocialization and the construction of identity. The analysis uses the method of qualitative content analysis with the usage of deductive category application. That means prior formulated categories were used and those were being connected with the text. At the end of this thesis, the...
Properties and functions of agnoprotein of polyomaviruses
Zosinčuková, Tereza ; Forstová, Jitka (advisor) ; Vinšová, Barbora (referee)
Polyomaviridae family includes small DNA viruses with simple structure and a small genome encoding only a few proteins. These proteins include large T and small T antigens, as well as 2 to 3 structural proteins known as VP1, VP2 and VP3. In addition, some members of the Polyomaviridae family encode in their genome a small non-structural protein called agnoprotein. Among human polyomaviruses, agnoprotein is present in BK polyomavirus and JC polyomavirus. These viruses are the causative agents of some serious diseases in immunocompromised humans and therefore, they are the subject of intensive research. Simian vacuolating virus 40 is another example of a virus which encodes the agnoprotein. Agnoprotein is capable to manipulate its host cell, disrupt vesicle transport and is also crucial for viral replication and transcription. It appears to play an important role in the morphogenesis of virions and/or in their release from the cell. This paper comprehensively summarizes the latest insights into the properties and functions of the agnoprotein BK polyomavirus, JC polyomavirus and SV40 virus, focusing on the production of this protein during infection, its structure, posttranslational modifications, cell localization, interaction partners and the overall importance of this enigmatic protein for the...
Conspiracy theories as quasireligion
Hlaváčová, Kateřina ; Kostičová, Zuzana (advisor) ; Gebelt, Jiří (referee)
Conspiracy theories are an old-new phenomenon which has gained its importance and specific character over the last three centuries. Unofficially, they have become an alternative tradition of the interpretation of historical events connected with an alternative form of spirituality, known as conspirituality. This manner of the interpretation usually holds the power when the consensually accepted worldview loses its plausibility for the concrete person or group. Conspiracy theories are the verbalization of a certain way of thinking and action which depends on it. Most often, they are manifested in the form of myths. That is understood as one of the dominant structures, commonly connected with traditionally perceived religion. From this point of view and in terms of the function associated with conspiracy narratives, conspiracy theories are examined as functional and structural equivalents of religion. These functions are especially the defense of the order (nomos), differentiation of the outer reality or the explanation of the presence of Evil in the world. In addition, they can also become a medium or tool of social actors in power relations. This thesis represents the complementary overview of the contemporary approaches in the study of religion discourse, which deals with unconventional religiosity...
Management of Building Order
Stará, Michaela ; Poul, Pavel (referee) ; Waldhans, Miloš (advisor)
The topic of the bachelor thesis is the management of the construction contract. The bachelor thesis is divided on the theoretical and practical part. The theoretical part explains the principle of project management, contains information about life cycle of the project, about contractual relations between projectsand its sources. In the practical part describes the preparation and management of the public order for school construction. The output of the practical part is a time schedule is displayed, showing a difference from the original plan.

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