National Repository of Grey Literature 842 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Advanced Methods of Perfusion Analysis in MRI
Macíček, Ondřej ; Frollo, Ivan (referee) ; Mikl, Michal (referee) ; Jiřík, Radovan (advisor)
This dissertation deals with quantitative perfusion analysis of MRI contrast-enhanced image time sequences. It focuses on two so far separately used methods -- Dynamic contrast-enhanced MRI (DCE-MRI) and Dynamic susceptibility contrast MRI (DSC-MRI). The common problem of such perfusion analyses is the unreliability of perfusion parameters estimation. This penalizes usage of these unique techniques on a regular basis. The presented methods are intended to improve these drawbacks, especially the problems with quantification in DSC in case of contrast agent extravasation and instability of the deconvolution process in DCE using advanced pharmacokinetic models. There are a few approaches in literature combining DCE and DSC to estimate new parameters of the examined tissue, namely the relaxivity of the vascular and of the interstitial space. Originally, in this scheme, the 2CXM DCE model was used. Here various models for DCE analysis are tested keeping in mind the DCE-DSC combination. The ATH model was found to perform better in this setting compared to 2CXM. Finally, the ATH model was used in alternating DCE-DSC optimization algorithm and then in a truly fully simultaneous DCE-DSC. The processing was tested using simulated and in-vivo data. According to the results, the proposed simultaneous algorithm performs better in comparison with sequential DCE-DSC, unleashing full potential of perfusion analysis using MRI.
Health centre Proficlinic
Růžička, Věroslav ; Kalánek, Jiří (referee) ; Brzoň, Roman (advisor)
The subject of my diploma thesis is the processing of project documentation of the construction part for the realization of the new build private health centre Proficlinic in the outskirts of České Budějovice. It is a two-storey partially basement building. On the first floor there is a pharmacy with the preparation of cytostatics, surgery x-ray and facilities for staff. On the underground floor there are technical facilities for new buildings and storage facilities. On the second floor there are individual surgeries and day care center of oncology. The ceilings are made of prestressed panels. The roof of the building is flat single-skinned.
Oncolytic viruses in cancer immunotherapy
Zupko, Jakub ; Bartůňková, Jiřina (advisor) ; Janovec, Václav (referee)
Oncolytic virotherapy is a field dedicated to exploiting viruses in the battle against cancer, where their specific cytolytic effects are sorely needed. This work focuses on the mechanisms and limitations of oncolytic virotherapy, on the recent advances in the field and on the potential oncolytic viruses hold for the future.
Respite Centre of Krtek (Mole) Children's Oncology Foundation
Čánský, Pavel ; Mašek, Radomír (referee) ; Marek, Jiří (advisor)
The diploma thesis deals with the design of the building of the Center for Children's Oncology Endowment Fund Krtek (Mole) at the crossing of Milady Horákové and Francouzské streets in Brno. Emphasis is placed on a detailed solution of operational, functional and capacity needs, which are individual requirements of a particular endowment fund.
The issue of skin care in connection with radiotherapy.
This bachelor thesis deals with one of the most frequent complications of patients undergoing radiotherapy. Despite all the progress and development of this treatment, unfortunately, the radiation influences not only the tumour itself but has an effect on surrounding healthy tissue as well. Post-radiational reaction on skin arises. The aim of this thesis is to discover particularities of nursing care of patients with post-radiational changes on skin, to discover practical experience of medical personnel with products for prevention and treatment of post-radiational changes on skin and discover the role of nurses in the issues of skin treatment of patients undergoing the radiotherapy. The thesis is divided in theoretical part and empirical part. The theoretical part deals with types of tumours, diagnostics and treatment, undesirable effects of ionizing radiation and nursing care of patients undergoing the radiotherapy. A qualitative research inquiry was accomplished by means of semi structured interviews in the empirical part. The research sample was intentionally chosen and the criterion for the choice was a nurse working at an oncological inpatient department or at a radiotherapeutic outpatient department. The research group was created by 6 nurses from different medical facilities in the Czech Republic. Four categories and seven subcategories were created while assessing the interviews. The results of the research inquiry show that the most recommended product for preventive skin treatment is a Cavilon spray. It is important to use water-based products instead of oil-based ones. Under the principles of skin treatment, it is most frequently recommended to wear cotton and loose-fitting clothes without laces and shave only with electric razor not with razor blades. Furthermore, the careful hygiene with cold water without using a soap or scented soap is also important. It is important for every medical staff member to approach individually to every patient's needs. One of the main roles of a nurse is the right patient instruction, right evaluation of skin damage and skin reaction treatment. We recommend to lay stress on the prevention in the form of instruction of the patient already before the start of the radioactive treatment.
Influence of fetal microchimerism on breast carcinoma in mothers
Šůchová, Anna-Marie ; Hromadníková, Ilona (advisor) ; Balounová, Jana (referee)
Fetal microchimerism is a condition where fetal cells are present in the body of the mother, they are transmitted during pregnancy and may persist for several decades after parturition. Their presence affects the immune system of the mother, which is investigated in both autoimmune and tumor diseases. This work, as a literature review, summarizes the current knowledge of the effect of fetal microchimerism on breast carcinomas in mothers, which is one of the most common cancer in women worldwide. It is based on studies that examined the presence of fetal cells in peripheral blood and neoplastic maternal tissues. While the correlation between the presence of fetal microchimerism in peripheral blood and breast cancer suggests a possible protective role, the data on the investigation of the same correlation in neoplastic tissue are not so unambiguous. Some of them suggest a protective role, others have a negative role. Key words - fetal microchimerism, breast carcinoma, pathogenesis, oncology, tumor
Specification of nutrition a patients with oncological disaeses of blood.
A common problem with oncological diseases is a lack of nutrition or refusal to take food caused by changes in taste or other complications associated with treatment. This is also true with oncological blood diseases. Because of the influence of their treatment, the people with these diseases frequently lose their appetite and suffer from nausea, often strong enough to induce vomiting, as well as diarrhea or complete change of taste. Immediately after the treatment they can feel a so called "metallic" taste in the mouth. This thesis focuses on analyzing whether the intake is sufficient in such cases. For qualitative research, we used directive interview and collected anthropometric data and sample menus from respondents with oncological blood diseases, which are subsequently calculated Nutriservis. The interview focused primarily on nutrition, but there were also some questions about treatment, as well as family and personal medical history. Comparing the documented menus from the respondents with the calculated values of the recommended intake for each person had a predictable result. All respondents had a lower intake of energy than was calculated for them Protein was taken by 77.7% people (i.e., 7 out of 9 people), which is also a small amount, while fat was taken by 44.4% (4 of 9 people), which is larger amount than recommended. None of the respondents achieved the recommended amount of carbohydrates. We can therefore say that, despite the efforts of doctors and nutritional therapists, people with oncological blood diseases still suffer from poor nutrition. This situation can only be prevented by giving the people with these diseases enough information about the frequent complications that occur and the risks associated with them. In addition, it is necessary to monitor these people and, in cases of major weight loss, inform their doctor, who will consider the administration of artificial nutrition.
Modeling and Signal Processing in Dynamic Contrast Enhanced Magnetic Resonance Imaging
Kratochvíla, Jiří ; Šroubek,, Filip (referee) ; Tintěra,, Jaroslav (referee) ; Jiřík, Radovan (advisor)
The theoretical part of this work describes perfusion analysis of dynamic contrast enhanced magnetic resonance imaging from data acquisition to estimation of perfusion parameters. The main application fields are oncology, cardiology and neurology. The thesis is focused on quantitative perfusion analysis, specifically it contributes to solving of the the main challenge of this method – correct estimation of the contrast-agent concentration sequence in the arterial input of the region of interest (arterial input function). The goals of the thesis are stated based on literature review and on the expertise of our group. Blind deconvolution is selected as the method of choice. In the practical part of this thesis, a new method for arterial input function identification based on blind deconvolution is proposed. The method is designed for both preclinical and clinical applications. It was validated on synthetic, preclinical and clinical data. Furthermore, possibilities of the longer temporal sampling provided by blind deconvolution were analyzed. This can be used for improved spatial resolution and possibly for higher SNR. For easier deployment of the proposed methods into clinical and preclinical use, a software tool for perfusion data processing was designed.

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